An evaluation of the links between microRNA, autophagy, and epilepsy
An evaluation of the links between microRNA, autophagy, and epilepsy
复制标题
microRNA、自噬和癫痫之间联系的评估
DOI：
10.1515/revneuro-2014-0062
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发表时间：
2015-04-01
影响因子：
4.1
通讯作者：
Mu, Dezhi
中科院分区：
文献类型：
--
作者：
Gan, Jing;Qu, Yi;Mu, Dezhi
癫痫是一种严重的慢性神经系统疾病，其特征是由大脑内异常和高度同步的神经元放电引起的反复无端发作。小的非编码rna，被称为微rna，在癫痫发生中起着至关重要的作用，具有潜在的贡献，作为有价值的生物标志物和治疗癫痫的靶点。为了维持细胞内稳态，细胞器、蛋白质、蛋白质复合物/低聚物和病原体等细胞成分通过自噬过程被递送到溶酶体进行降解，这一过程在癫痫应激下起保护或有害作用。几种自噬机制与癫痫发生有关，包括雷帕霉素途径的哺乳动物靶点，异常底物积累和癫痫网络的形成。此外，通过microRNAs （miRNAs）调控自噬代表了一种通过“自噬irnas”的新型转录后调控机制。自噬与miRNA之间的相关性增加了我们对人类疾病潜在发病机制的理解。在此，我们对miRNA、自噬和癫痫之间的相关性进行综述，为进一步研究miRNA-自噬通路参与癫痫病理生理提供坚实的基础。
Abstract Epilepsy is a serious chronic neurologic disorder characterized by recurrent unprovoked seizures resulting from abnormal and highly synchronous neuronal discharges within the brain. Small noncoding RNAs, called microRNAs, play vital roles in epileptogenesis, with potential contributions as valuable biomarkers and targets for the treatment of epilepsy. To maintain cellular homeostasis, cellular components, such as organelles, proteins, protein complexes/oligomers, and pathogens, are delivered to the lysosome for degradation through a process called autophagy, which plays either a protective or a harmful role under epileptic stress. Several autophagic mechanisms have been implicated in epileptogenesis, including the mammalian target of rapamycin pathway, aberrant substrate accumulation, and the formation of epileptic networks. In addition, the regulation of autophagy through microRNAs (miRNAs) represents a novel posttranscriptional regulatory mechanism through ‘autophagamiRNAs’. The correlation between autophagy and miRNA has increased our understanding of the underlying pathogenesis of human diseases. Here, we review the current findings regarding the correlations between miRNA, autophagy, and epilepsy to provide a solid foundation for further examination of the miRNA-autophagy pathway involved in epilepsy pathophysiology.