Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly
Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly
复制标题
浓缩聚合物刷修饰纤维素纳米纤维通过控制自组装促进人间充质干细胞成软骨分化
DOI：
10.1039/d1tb02307a
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发表时间：
2022
影响因子：
7
通讯作者：
Yoshikawa Chiaki
中科院分区：
文献类型：
--
作者：
Nonsuwan Punnida;Nishijima Nanami;Sakakibara Keita;Nakaji-Hirabayashi Tadashi;Yoshikawa Chiaki
为了开发用于关节软骨再生的新的三维（3D）细胞培养系统，采用浓缩的聚（苯乙烯磺酸钠盐）刷修饰的纤维素纳米纤维作为用于人间充质干细胞（hMSCs）自组装的构件。通过控制hMSC自组装形成独特的3D细胞结构，如巨球和片。
In order to develop new three-dimensional (3D) cell culture systems for articular cartilage regeneration, concentrated poly(styrene sulfonate sodium salt) brush-modified cellulose nanofibers were employed as building blocks for the self-assembly of human mesenchymal stem cells (hMSCs). Unique 3D cellular structures, such as giant spheres and sheets, were formed by controlling hMSC self-assembly.