Change point-cure models with application to estimating the change-point effect of age of diagnosis among prostate cancer patients.
Change point-cure models with application to estimating the change-point effect of age of diagnosis among prostate cancer patients.
复制标题
改变点治疗模型并应用于估计前列腺癌患者诊断年龄的变点效应。
DOI：
10.1080/02664763.2011.626849
复制
发表时间：
2012
影响因子：
1.5
通讯作者：
Tiwari,Ram
中科院分区：
文献类型：
--
作者：
Othus,Megan;Li,Yi;Tiwari,Ram
Previous research on prostate cancer survival trends in the United States National Cancer Institute's Surveillance Epidemiology and End Results database has indicated a potential change-point in the age of diagnosis of prostate cancer around age 50. Identifying a change-point value in prostate cancer survival and cure could have important policy and health care management implications. Statistical analysis of this data has to address two complicating features: change-point models are not smooth functions and so present computational and theoretical difficulties; and models for prostate cancer survival need to account for the fact that many men diagnosed with prostate cancer can be effectively cured of their disease with early treatment. We develop a cure survival model that allows for change-point effects in covariates to investigate a potential change-point in the age of diagnosis of prostate cancer. Our results do not indicate that age under 50 is associated with increased hazard of death from prostate cancer.
