The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection.
The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection.
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DOI：
10.3389/fimmu.2018.02322
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发表时间：
2018
影响因子：
7.3
通讯作者：
Jiang Y
中科院分区：
文献类型：
--
作者：
Chen X;Lin M;Qian S;Zhang Z;Fu Y;Xu J;Han X;Ding H;Dong T;Shang H;Jiang Y
抗体依赖细胞介导的细胞毒(ADCC)是一种主要由自然杀伤(NK)细胞介导的免疫反应，可杀伤靶细胞，对抗肿瘤和病毒感染。然而，ADCC在应对原发HIV感染中的作用还知之甚少。在本研究中，我们探讨了85名HIV感染者的ADCC反应，并对其特征进行了评估，其中包括42名原发感染者。我们的结果表明，ADCC发生在急性感染期间，对单一多肽的最早ADCC反应在52天。有ADCC反应的初次HIV感染者的病毒设定点低于没有ADCC反应的人，功能分析表明ADCC反应可以显著抑制初次HIV感染期间的病毒感染。确定了引起ADCC反应的HIV表位，并从HIV Env蛋白的三维结构表面鉴定了三个相对保守的表位(HNVWATYACVPTDPNPQE、TSVIKQACPKISFDPIPI和VVSTQLLNGSLAEEEII)。总体而言，我们的数据表明，ADCC的反应可能对从感染的早期阶段控制艾滋病毒具有重要意义。这些发现值得进一步研究，并将有助于改进针对艾滋病毒感染的疫苗或治疗干预措施。
Antibody-dependent cell-mediated cytotoxicity (ADCC) is an immune response largely mediated by natural killer (NK) cells that can lyse target cells and combat tumors and viral infections. However, the role of ADCC in response to primary HIV infection is poorly understood. In the present study, we explored the ADCC response and evaluated its characteristics in 85 HIV-infected individuals, including 42 with primary infections. Our results showed that ADCC occurs during acute infection, and the earliest ADCC response to a single peptide was detected at 52 days. Primary HIV-infected individuals exhibiting ADCC responses had lower viral set points than those with no ADCC response, and functional analyses demonstrated that the ADCC response could significantly inhibit viral infection during primary HIV infection. HIV epitopes that provoked the ADCC response were determined and three relatively conserved epitopes (HNVWATYACVPTDPNPQE, TSVIKQACPKISFDPIPI, and VVSTQLLLNGSLAEEEII) from the surface of the three-dimensional structure of the HIV Env protein were identified. Overall, our data indicate that ADCC responses may be significant for the control of HIV from an early stage during infection. These findings merit further investigation and will facilitate improvements in vaccines or therapeutic interventions against HIV infection.
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影响因子：
3.7
作者：
Serna-Bolea C;de Deus N;Acácio S;Muñoz J;Nhalungo D;Letang E;Alonso P;Naniche D
通讯作者：
Naniche D
DOI：
10.1073/pnas.1217609110
发表时间：
2013-01-02
影响因子：
11.1
作者：
Guan, Yongjun;Pazgier, Marzena;Lewis, George K.
通讯作者：
Lewis, George K.
影响因子：
5.4
作者：
Wang, I-K.;Wu, Y-Y.;Lin, H-C.
通讯作者：
Lin, H-C.
影响因子：
3.8
作者：
Cui, Hualu;Geng, Wenqing;Shang, Hong
通讯作者：
Shang, Hong
HIV-1 疫苗功效试验的免疫相关分析。
DOI：
10.1056/nejmoa1113425
发表时间：
2012-04-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Haynes BF;Gilbert PB;McElrath MJ;Zolla-Pazner S;Tomaras GD;Alam SM;Evans DT;Montefiori DC;Karnasuta C;Sutthent R;Liao HX;DeVico AL;Lewis GK;Williams C;Pinter A;Fong Y;Janes H;DeCamp A;Huang Y;Rao M;Billings E;Karasavvas N;Robb ML;Ngauy V;de Souza MS;Paris R;Ferrari G;Bailer RT;Soderberg KA;Andrews C;Berman PW;Frahm N;De Rosa SC;Alpert MD;Yates NL;Shen X;Koup RA;Pitisuttithum P;Kaewkungwal J;Nitayaphan S;Rerks-Ngarm S;Michael NL;Kim JH
通讯作者：
Kim JH