Bioinspired amphiphilic phosphate block copolymers as non-fluoride materials to prevent dental erosion.
Bioinspired amphiphilic phosphate block copolymers as non-fluoride materials to prevent dental erosion.
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DOI：
10.1039/c4ra08377f
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发表时间：
2014-01-01
期刊：
影响因子：
3.9
通讯作者：
Kilpatrick-Liverman L
中科院分区：
文献类型：
--
作者：
Lei Y;Wang T;Mitchell JW;Zaidel L;Qiu J;Kilpatrick-Liverman L
受某些天然蛋白质，如酪蛋白磷酸肽或釉原蛋白能够防止牙齿侵蚀(矿物质流失)和增强牙齿再矿化的事实的启发，合成的两亲双嵌段共聚物含有亲水性的甲基丙烯酰氧乙基磷酸酯嵌段(MOEP)和疏水的甲基丙烯酸甲酯嵌段(MMA)，被设计为一种新型的非氟化剂，以防止酸性条件下的牙齿侵蚀。用凝胶渗透色谱(GPC)、傅里叶变换红外光谱(FTIR)和核磁共振(NMR)对可逆加成-片段转移(RAFT)聚合合成的聚合物的结构进行了表征。两亲性嵌段共聚物中的亲水性PMOEP嵌段与牙釉质表面紧密结合，而PMMA嵌段形成疏水外壳，防止酸蚀对牙釉质的侵蚀，从而防止/减少酸蚀。与未处理的对照相比，聚合物处理不仅有效地减少了羟基磷灰石(HAP)的矿物质损失，而且还保护了暴露在酸中的釉质标本的表面形态。此外，实验结果证实，低pH值和高聚合物浓度有利于聚合物结合。因此，初步数据表明，这种新型的两亲性两嵌段共聚物有可能作为一种无氟成分用于口腔清洁或牙膏，以防止/减少牙齿侵蚀。
Inspired by the fact that certain natural proteins, e.g. casein phosphopeptide or amelogenin, are able to prevent tooth erosion (mineral loss) and to enhance tooth remineralization, a synthetic amphiphilic diblock copolymer, containing a hydrophilic methacryloyloxyethyl phosphate block (MOEP) and a hydrophobic methyl methacrylate block (MMA), was designed as a novel non-fluoride agent to prevent tooth erosion under acidic conditions. The structure of the polymer, synthesized by reversible addition-fragment transfer (RAFT) polymerization, was confirmed by gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), and nuclear magnetic resonance spectroscopy (NMR). While the hydrophilic PMOEP block within the amphiphilic block copolymer strongly binds to the enamel surface, the PMMA block forms a hydrophobic shell to prevent acid attack on tooth enamel, thus preventing/reducing acid erosion. The polymer treatment not only effectively decreased the mineral loss of hydroxyapatite (HAP) by 36–46% compared to the untreated control, but also protected the surface morphology of the enamel specimen following exposure to acid. Additionally, experimental results confirmed that low pH values and high polymer concentrations facilitate polymer binding. Thus, the preliminary data suggests that this new amphiphilic diblock copolymer has the potential to be used as a non-fluoride ingredient for mouth-rinse or toothpaste to prevent/reduce tooth erosion.