Mismatched unrelated alternative donors for hematological malignancies.

Mismatched unrelated alternative donors for hematological malignancies.
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血液系统恶性肿瘤的不匹配的无关替代供体。

DOI:
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发表时间:
2016
期刊:
Seminars in hematology (Print)
影响因子:
--
通讯作者:
J. Finke
J. Finke
中科院分区:
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文献类型:
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作者:
Henning Sebastian Schäfer;J. Finke

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对于大多数血液恶性肿瘤,同种异体造血细胞移植(HCT)是唯一的治疗选择。兄弟姐妹捐献者一直是成年患者的标准。由于没有适合所有患者的家庭供体,因此 HCT 对替代供体的需求很大。幸运的是,多年来,无关志愿者捐献者登记的可用性不断扩大,并且匹配的无关捐献者 (MUD) 的 HCT 结果与匹配的相关捐献者 (MRD) 的结果相当。尽管如此,仍有许多患者缺乏匹配的供体。为了增加移植的适用性,错配无关供体(MMURD)、脐带血干细胞产品和半相合相关供体等替代供体已被广泛使用。本综述旨在深入了解 MMUD 供体用于 HCT 的情况并总结现有数据。
For the majority of hematologic malignancies allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment option. Sibling donors have been the standard for adult patients. Since there is not a suitable family donor for all patients, the need for alternative donors for HCT is great. Fortunately, the availability of unrelated volunteer donor registries has expanded over the years and the results of HCT with matched unrelated donors (MUD) are comparable to the results with matched related donors (MRD). Nevertheless, there are many patients lacking a well-matched donor. To increase the applicability of transplantation, alternative donors such as mismatched unrelated donors (MMURD), cord blood stem cell products and haploidentical related donors have been widely used. This review seeks to give insights into the use of MMUD donors for HCT and summarize the existing data.
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