Serotonin receptors influencing cell proliferation in the jejunal crypt epithelium and in colonic adenocarcinomas.
Serotonin receptors influencing cell proliferation in the jejunal crypt epithelium and in colonic adenocarcinomas.
复制标题
血清素受体影响空肠隐窝上皮和结肠腺癌的细胞增殖。
作者：
P. Tutton;D. Barkla
5-羟色胺先前已被证明刺激空肠隐窝上皮和结肠肿瘤中的细胞增殖。将5-羟色胺受体分为D组和M组的原始分类不利于理解这些观察结果。在本报告中考虑了5-羟色胺受体的最新分类5 HT 1和5 HT 2组。在证据的平衡上，似乎相似的受体介导了所考虑的两种组织中对5-羟色胺的反应，并且这些受体类似于5 HT 1组的受体。这种受体通常与腺苷酸环化酶正连接。
Serotonin has previously been shown to stimulate cell proliferation in the jejunal crypt epithelium and in colonic tumours. The original classification of serotonin receptors into D and M groups was not conductive to the understanding of these observations. The more recent classification of serotonin receptors into 5HT1 and 5HT2 groups is considered in this report. On the balance of evidence it appears that similar receptors mediate the response to serotonin in the two tissues under consideration and that these receptors resemble those of the 5HT1 group. Such receptors are usually positively linked to adenylate cyclase.