N-Halamine-Containing Electrospun Fibers Kill Bacteria via a Contact/Release Co-Determined Antibacterial Pathway
N-Halamine-Containing Electrospun Fibers Kill Bacteria via a Contact/Release Co-Determined Antibacterial Pathway
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DOI：
10.1021/acsami.6b08431
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发表时间：
2016-11-23
影响因子：
9.5
通讯作者：
Dong, Alideertu
中科院分区：
文献类型：
--
作者：
Bai, Rong;Zhang, Qing;Dong, Alideertu
N-卤胺类抗菌材料在控制微生物污染方面具有重要作用，但其合成工艺复杂，抗菌作用不明显，限制了其实际应用。本研究通过一步静电纺丝法在不添加任何添加剂的情况下合成了新型的含N-卤胺的抗菌聚合物纤维。通过调节前驱体的浓度和聚合物的分子量，可以调节初生含N-卤胺纤维的形态和尺寸。初生纤维对革兰氏阳性菌和革兰氏阴性菌均表现出抗菌活性。使用不同的生物化学技术的抗菌评估后，接触/释放共同确定的杀伤作用的组合机制被证明为纺含N-卤胺的纤维。这种复合作用机制可使N-卤胺通过接触作用和/或释放作用对细菌进行攻击，使初生纤维在干燥或潮湿环境下的抗菌领域具有广泛的应用。循环抗菌试验表明，初生纤维经过5次循环后仍具有抗菌性能。
N-Halamine-based antibacterial materials play a significant role in controlling microbial contamination, but their practical applications are limited because of their complicated synthetic process and indistinct antibacterial actions. In this study, novel antibacterial N-halamine-containing polymer fibers were synthesized via an one-step electrospinning of N-halamine-containing polymers without any additives. By adjusting the concentration of precursor and the molecular weight of polymers, the morphology and size of the as-spun N-halamine-containing fibers can be regulated. The as-spun fibers showed antibacterial activity against both Gram-positive and Gram-negative bacteria. After an antibacterial assessment using different biochemical techniques, a combined mechanism of contact/release co-determined killing action was evidenced for the as-spun N-halamine-containing fibers. With the aid of contact action and/or release action, this combined mechanism can allow N-halamines to attack bacteria, making the as spun fibers wide in the application of antibacterial fields, whatever it is in dry or wet environment. Also, a recycle antibacterial test demonstrated that the as-spun fibers can still offer antibacterial property after five recycle experiments.