Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora -: I.: Taxonomy, fermentation, isolation and physico-chemical and biological properties
Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora -: I.: Taxonomy, fermentation, isolation and physico-chemical and biological properties
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DOI：
10.7164/antibiotics.51.394
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发表时间：
1998-04-01
影响因子：
3.3
通讯作者：
Oki, T
中科院分区：
文献类型：
--
作者：
Kajiura, T;Furumai, T;Oki, T
菌株TP-A0121产生一种新的酪氨酸激酶抑制剂复合物，命名为hibarimicins A、B、C、D和G，被认为是玫瑰小双孢菌的一个新亚种，命名为玫瑰小双孢菌玫瑰亚种（Microbispora rosea subsp.）。希巴莱亚，提出了。Hibarimicins A、B、C和D特异性抑制src酪氨酸激酶活性，而不影响蛋白激酶A或蛋白激酶C。它们还显示出体外抗革兰氏阳性细菌和抗肿瘤活性。Hibarimicin A、B、C、D和G的分子式分别为C85 H112 O37、C85 H112 O37、C83 H110 O36。C85 H112 O38和C85 H112 O39。
Strain TP-A0121 which produces a complex of novel tyrosine kinase inhibitors designated hibarimicins A, B, C, D and G was considered to be a new subspecies of Microbispora rosea, and the name, Microbispora rosea subsp. hibaria, was proposed. Hibarimicins A, B, C and D specifically inhibited the src tyrosine kinase activity without affecting protein kinase A or protein kinase C. They also showed in vitro anti-Gram-positive bacterial and antitumor activities. The molecular formulae of hibarimicins A, B, C, D and G were assigned to be C85H112O37, C85H112O37, C83H110O36. C85H112O38, and C85H112O39 respectively.