The effect of dietary magnesium and caseinphosphopeptides on bone metabolism in rats
The effect of dietary magnesium and caseinphosphopeptides on bone metabolism in rats
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膳食镁和酪蛋白磷酸肽对大鼠骨代谢的影响
DOI：
10.1039/c7fo00842b
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发表时间：
2017-12-01
期刊：
影响因子：
6.1
通讯作者：
Cao, Yong
中科院分区：
文献类型：
--
作者：
Liu, Guo;Miao, Jianyin;Cao, Yong
膳食镁（Mg）或酪蛋白磷酸肽（CPP）对骨代谢的影响已有报道。然而，很少有研究同时补充Mg和CPP的影响。将63只3周龄Sprague-Dawley雄性大鼠分为7组，饲喂指定的饲料45天。分析研究对象的身体特征、骨理化指标及与骨代谢相关的骨代谢指标。我们发现，首先，膳食镁缺乏导致骨形成增加和骨吸收减少。第二，膳食镁或CPP补充剂促进骨形成和防止骨吸收。第三，膳食中补充镁与CPPs也起到促进骨形成和防止骨吸收的作用。HS-Mg-CPP组（0.2%Mg、0.1%CPPs）对股骨长度、血清甲状旁腺激素水平和尿脱氧吡啶啉有协同作用。与对照组相比，HS-Mg-CPP组股骨长度增加6%，远高于HS-Mg（1%）或CPP（5%）。与对照组相比，HS-Mg-CPP组血清甲状旁腺素含量的诱导率为33%，高于HS-Mg组（19%）和CPP组（23%）。与对照组相比，HS-Mg-CPP组的脱氧吡啶啉含量（43%）显著高于HS-Mg（8%）或CPP（16%）。总之，我们的研究结果表明，高剂量的镁（0.2%）和CPPs（0.1%）的组合产生协同效应的股骨长度，血清甲状旁腺激素水平和尿脱氧吡啶啉在大鼠，这是重要的是更好地了解镁和CPPs对骨代谢的影响。
The effect of dietary magnesium (Mg) or caseinphosphopeptides (CPPs) on bone metabolism has been reported. However, few studies have investigated the effects of simultaneous supplementation of Mg and CPPs. Sixty-three 3-week-old Sprague-Dawley male rats were divided into seven groups and fed a specified diet for 45 days. Body characteristics, bone physicochemical indicators, and bone metabolism indicators relative to bone metabolism were analyzed. We found that, first, a dietary Mg deficiency resulted in increased bone formation and decreased bone resorption. Second, dietary Mg or CPP supplementation promoted bone formation and prevented bone resorption. Third, dietary Mg supplementation with CPPs also functioned to enhance bone formation and prevent bone resorption. There were synergistic effects on femur length, serum parathyroid hormone level and urinary deoxypyridinoline of the HS-Mg-CPP group (0.2% Mg, 0.1% CPPs). The increase in the femur length of the HS-Mg-CPP group compared with the control group was 6% which was much higher than that of HS-Mg (1%) or CPPs (5%). The induction in serum parathyroid hormone content in the HS-Mg-CPP group was 33% compared with the control group which was higher than that of the induction of the HS-Mg (19%) or CPP (23%) group. The induction in the deoxypyridinoline content of the HS-Mg-CPP (43%) group compared with the control group was remarkably higher than that of HS-Mg (8%) or CPPs (16%). Overall our results demonstrated that high doses of Mg (0.2%) and CPPs (0.1%) in combination produced synergistic effects on femur length, serum parathyroid hormone level and urinary deoxypyridinoline in rats, which is important for a better understanding of the effect of Mg and CPPs on bone metabolism.