PERSISTENCE IN HUMANS OF ANTIBODY TO SUBTYPES OF VENEZUELAN EQUINE ENCEPHALOMYELITIS (VEE) VIRUS AFTER IMMUNIZATION WITH ATTENUATED (TC-83) VEE VIRUS-VACCINE
PERSISTENCE IN HUMANS OF ANTIBODY TO SUBTYPES OF VENEZUELAN EQUINE ENCEPHALOMYELITIS (VEE) VIRUS AFTER IMMUNIZATION WITH ATTENUATED (TC-83) VEE VIRUS-VACCINE
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DOI：
10.1093/infdis/136.3.354
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发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
EDELMAN, R
中科院分区：
文献类型：
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作者：
BURKE, DS;RAMSBURG, HH;EDELMAN, R
用20名志愿者接种TC-83 VEE病毒减毒疫苗7年或9年后的血清研究了VEE病毒亚型抗体的持久性。血清学模式进行了比较与其他10人的血清样品，获得28天后接种TC-83病毒。接种者没有其他已知的A组虫媒病毒暴露。中和抗体滴度≥在所有长期和短期疫苗接种者中，针对同源TC-83病毒株测量了1：10。在两组疫苗接种者中，抗体阳性者的百分比及其对流行亚型I-A、I-B和I-C的抗体的几何平均滴度高于对流行亚型I-D、I-E、II、III和IV的滴度。与短期接种者相比，长期接种者中可检测到与地方流行毒株反应的中和抗体的比例更低。这些结果表明，在95%-100%的接种者中，TC-83病毒和密切相关的动物流行病变体的中和抗体持久循环。相对较低的抗体转化率和对抗原性更远的VEE病毒地方流行亚型的抗体丧失表明，接种疫苗者可能对这些毒株感染的保护效果较差。
The persistence of antibody to VEE virus subtypes was studied using sera of 20 volunteers inoculated 7 or 9 yr previously with attenuated TC-83 VEE virus vaccine. Serological patterns were compared with those of 10 other persons from whom samples of serum were obtained 28 days after vaccination with TC-83 virus. Vaccinees had no other known exposure to a group A arbovirus. Titers of neutralizing antibody of .gtoreq. 1:10 were measured against the homologous TC-83 strain of virus in all long- and short-term vaccinees. In both groups of vaccinees, the percentage of antibody-positive persons and their geometric mean titers of antibody to the epizootic subtypes I-A, I-B and I-C were higher than titers to the enzootic subtypes I-D, I-E, II, III and IV. Proportionally fewer long-term vaccinees than short-term vaccinees had detectable neutralizing antibody reactive with enzootic strains. These results reveal long-lasting circulation of neutralizing antibody to TC-83 virus and closely related epizootic variants in 95%-100% of vaccinees. The relatively lower rate of antibody conversion and the loss of antibody to more antigenically remote enzootic subtypes of VEE virus suggest that vaccinees may be less well protected against infection by these strains.