Long-Term Synaptic Plasticity in Rat Barrel Cortex
Long-Term Synaptic Plasticity in Rat Barrel Cortex
复制标题
大鼠桶状皮层的长期突触可塑性
DOI：
10.1093/cercor/bhu071
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yu Yan-Qin
中科院分区：
文献类型：
--
作者：
Han Yong;Huang Ming-De;Sun Man-Li;Duan Shumin;Yu Yan-Qin
老鼠产生扫胡须运动，以探索他们的环境和识别物体。在躯体感觉通路中，神经元活动由触须振动的频率调制。然而，节律性神经元活动在感觉信号脑处理中的潜在作用及其机制尚不清楚。在这里，我们表明，在麻醉大鼠的短时间内的节律性触须刺激导致增加或减少的对侧桶皮层的体感诱发电位（SEP）的振幅。SEP的可塑性变化具有频率依赖性和持续时间长的特点。触须对皮层诱发反应的长期增强是侧面的，但不是桶特异性的。将dl-2-amino-5-phosphopentanoic acid局部应用于桶状皮质揭示了成年大鼠触须-皮质的长期可塑性是N-甲基-d-天冬氨酸受体依赖性的。最有趣的是，在出生后第1-7天（P）而不是P29-35天修剪胡须损害了由100 Hz触须刺激诱导的长期可塑性。短时间的有节奏的触须刺激并没有引起丘脑场电位的持久可塑性。总之，我们的研究结果表明，自然的节奏胡须活动修改感觉信息处理在大脑皮层，提供了进一步的洞察感官知觉。
Rats generate sweeping whisker movements in order to explore their environments and identify objects. In somatosensory pathways, neuronal activity is modulated by the frequency of whisker vibration. However, the potential role of rhythmic neuronal activity in the cerebral processing of sensory signals and its mechanism remain unclear. Here, we showed that rhythmic vibrissal stimulation with short duration in anesthetized rats resulted in an increase or decrease in the amplitude of somatosensory-evoked potentials (SEPs) in the contralateral barrel cortex. The plastic change of the SEPs was frequency dependent and long lasting. The long-lasting enhancement of the vibrissa-to-cortex evoked response was side- but not barrel-specific. Local application ofdl-2-amino-5-phosphonopentanoic acid into the barrel cortex revealed that this vibrissa-to-cortex long-term plasticity in adult rats wasN-methyl-d-aspartate receptor-dependent. Most interestingly, whisker trimming through postnatal day (P)1–7 but not P29–35 impaired the long-term plasticity induced by 100 Hz vibrissal stimulation. The short period of rhythmic vibrissal stimulation did not induce long-lasting plasticity of field potentials in the thalamus. In conclusion, our results suggest that natural rhythmic whisker activity modifies sensory information processing in cerebral cortex, providing further insight into sensory perception.