Simple branched sulfur-olefins as chiral ligands for Rh-catalyzed asymmetric arylation of cyclic ketimines: highly enantioselective construction of tetrasubstituted carbon stereocenters.
Simple branched sulfur-olefins as chiral ligands for Rh-catalyzed asymmetric arylation of cyclic ketimines: highly enantioselective construction of tetrasubstituted carbon stereocenters.
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DOI：
10.1021/ja3110818
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发表时间：
2013-01
影响因子：
15
通讯作者：
Hui Wang;T. Jiang;Ming‐Hua Xu
中科院分区：
文献类型：
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作者：
Hui Wang;T. Jiang;Ming‐Hua Xu
新的、简单的、基于亚磺酰胺的支链烯烃配体已经被开发并成功地用于Rh催化的环酮亚胺的不对称芳基化反应，提供了高效和高对映选择性的途径来获得有价值的苯磺胺和含有立体生成的季碳中心的苯磺酰胺。这是第一个将硫烯烃配体应用于亚胺催化不对称加成反应的例子。
New, simple, sulfinamide-based branched olefin ligands have been developed and successfully used in Rh-catalyzed asymmetric arylations of cyclic ketimines, providing efficient and highly enantioselective access to valuable benzosultams and benzosulfamidates containing a stereogenic quaternary carbon center. This is the first example of applying a sulfur-olefin ligand in catalytic asymmetric addition of imines.