Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines.
Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines.
复制标题
重组冷适应甲型和乙型流感病毒活疫苗的初步研究。
DOI：
--
复制
发表时间：
1977
影响因子：
6.4
通讯作者：
J. Mitchell
中科院分区：
文献类型：
--
作者：
F. M. Davenport;A. V. Hennessy;H. F. Maassab;E. Minuse;Larry C. Clark;G. Abrams;J. Mitchell
将来自标准化冷适应亲本株的重组甲型和B型流感病毒减毒活疫苗单独和联合给予志愿者。疫苗病毒耐受性良好，作为良好的抗原发挥作用，并且未能传播给亲密的家庭接触者。在人类中传代一次后回收的39株分离株似乎具有遗传稳定性。在雪貂中进行的组织病理学研究的结果鼓励开发病毒减毒的动物模型。
Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.