4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT
4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT
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DOI：
10.1118/1.1639993
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发表时间：
2004-02-01
期刊：
影响因子：
3.8
通讯作者：
Chen, GTY
中科院分区：
文献类型：
--
作者：
Pan, T;Lee, TY;Chen, GTY
我们提出了一种新的扫描协议，用于生成受呼吸运动影响的4D-CT图像数据集。在数据采集期间使用电影扫描协议，并且使用两种配准方法将图像分类为时间相位。在沿头尾方向沿着1或2 cm长的多次采集中对体积成像。在每次采集中，连续采集扫描的时间间隔大于或等于平均呼吸周期加上用于图像重建的数据的持续时间。在CT扫描床平移期间关闭X射线，并重复采集，直到完全扫描规定体积。20 cm覆盖范围的扫描用八层CT大约需要1分钟，用四层CT大约需要2分钟。在数据采集之后，基于内部解剖匹配或外部呼吸信号将CT数据配准到呼吸相位中。内部方法根据连续呼吸周期中两个相邻位置之间CT图像中解剖结构的相关性配准数据。我们已经证明了该技术的ROI放置在该地区的隔膜。外部方法根据实时位置管理（RPM）呼吸门控系统（Varian Medical Systems，Palo Alto，CA）生成的外部记录呼吸信号配准图像数据。与先前报道的利用单层或多层CT的呼吸运动的前瞻性或回顾性成像相比，这里提出的4D-CT方法提供（1）比具有前瞻性门控的单层CT快三到六倍的更短的扫描时间;（2）较短的扫描时间，比先前报道的多层CT实施方式提高了2至4倍，以及（3）在呼吸周期的所有阶段上的图像。我们已经将扫描和配准方法应用于体模、动物和患者，初步结果表明扫描和配准方法的适用性。2004年，美国医学物理学家协会。
We propose a new scanning protocol for generating 4D-CT image data sets influenced by respiratory motion. A cine scanning protocol is used during data acquisition, and two registration methods are used to sort images into temporal phases. A volume is imaged in multiple acquisitions of 1 or 2 cm length along the cranial-caudal direction. In each acquisition, the scans are continuously acquired for a time interval greater than or equal to the average respiratory cycle plus the duration of the data for an image reconstruction. The x ray is turned off during CT table translation and the acquisition is repeated until the prescribed volume is completely scanned. The scanning for 20 cm coverage takes about 1 min with an eight-slice CT or 2 mins with a four-slice CT. After data acquisition, the CT data are registered into respiratory phases based on either an internal anatomical match or an external respiratory signal. The internal approach registers the data according to correlation of anatomy in the CT images between two adjacent locations in consecutive respiratory cycles. We have demonstrated the technique with ROIs placed in the region of diaphragm. The external approach registers the image data according to an externally recorded respiratory signal generated by the Real-Time Position Management (RPM) Respiratory Gating System (Varian Medical Systems, Palo Alto, CA). Compared with previously reported prospective or retrospective imaging of the respiratory motion with a single-slice or multi-slice CT, the 4D-CT method proposed here provides (1) a shorter scan time of three to six times faster than the single-slice CT with prospective gating; (2) a shorter scan time of two to four times improvement over a previously reported multi-slice CT implementation, and (3) images over all phases of a breathing cycle. We have applied the scanning and registration methods on phantom, animal and patients, and initial results suggest the applicability of both the scanning and the registration methods. 0 2004 American Association of Physicists in Medicine.