Attenuation of alcohol preference in alcohol-preferring rats by a novel TRH analogue, TA-0910.
Attenuation of alcohol preference in alcohol-preferring rats by a novel TRH analogue, TA-0910.
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通过新型 TRH 类似物 TA-0910 减弱酒精偏好大鼠的酒精偏好。
DOI：
10.1111/j.1530-0277.1992.tb01385.x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Mason,GA
中科院分区：
文献类型：
--
作者：
Rezvani,AH;Garbutt,JC;Shimoda,K;Garges,PL;Janowsky,DS;Mason,GA
实验研究了一种新的促甲状腺激素释放激素(TRH)类似物(TA-0910)对大鼠酒精摄入量的急性影响。在上午9：30一次性腹腔注射生理盐水或0.083.0 2、0.2 5、0.75 mg/kg的TA-0 910，测量大鼠对乙醇、水和食物的消耗量。TA-0910可剂量依赖性地减少乙醇摄入量，并相应增加用水量。只有最大剂量的TA-0910增加了总热量的摄入量。TA-0910不影响乙醇的药代动力学。这些发现表明TRH系统参与了酒精偏好，并提示中枢作用的TRH类似物可能在酒精中毒的治疗中具有治疗作用。
Experiments were performed to characterize the acute effect different doses of a novel thyrotropin‐releasing hormone (TRH) analogue (TA‐0910) on ethanol intake in rats. Selectively bred alcohol‐preferring (P) rats received a single intraperitoneal injection of normal saline or 0.083, 0.25 and 0.75 mg/kg of TA‐0910 at 9:30 AM, and their consumption of ethanol, water, and food was measured for hr. TA‐0910 dose‐dependently attenuated ethanol intake and commensurately increased water consumption. Only the highest dose TA‐0910 increased the total caloric intake. TA‐0910 did not affect the pharmacokinetics of ethanol. These findings indicate involvement of TRH systems in ethanol preference and suggest that centrally acting TRH analogues may be therapeutic in the treatment of alcoholism.