Tissue plasminogen activator and inflammation: from phenotype to signaling mechanisms.
Tissue plasminogen activator and inflammation: from phenotype to signaling mechanisms.
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发表时间：
2014-02
影响因子：
0.8
通讯作者：
Ling Lin;Kebin Hu
中科院分区：
文献类型：
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作者：
Ling Lin;Kebin Hu
在疾病状况中，炎症细胞，如嗜中性粒细胞、T细胞和单核细胞/巨噬细胞，响应于损伤线索而被募集，并通过转录因子的组合表达一系列促炎基因。组织型纤溶酶原激活剂（tPA）是丝氨酸蛋白酶家族的成员之一，已被证明作为细胞因子激活深刻的受体介导的信号传导事件。本文就tPA在各种炎症模型中的作用进行综述，并阐明其调控炎症的信号转导机制。
In disease conditions, inflammatory cells, such as neutrophils, T cells, and monocytes/macrophages, are recruited in response to injury cues and express panoply of proinflammatory genes through a combination of transcription factors. Tissue plasminogen activator (tPA), a member of the serine protease family, has been shown to act as cytokine to activate profound receptor-mediated signaling events. In this review, we will discuss the role of tPA in inflammation in various models, and illuminate its signaling mechanisms underlying its modulation of inflammation.