Human mast cells modulate proliferation and cytokine production by CD8+ T lymphocytes
Human mast cells modulate proliferation and cytokine production by CD8+ T lymphocytes
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DOI：
10.1159/000237575
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发表时间：
1997-01-01
影响因子：
2.8
通讯作者：
Out, TA
中科院分区：
文献类型：
--
作者：
dePaterHuijsen, FL;deRiemer, MJ;Out, TA
背景在过敏性哮喘患者中，肥大细胞和T淋巴细胞都被认为参与了呼吸道路径-生理过程。通过变应原结合的肥大细胞IgE受体的交联会导致随后的介质释放。除了对支气管收缩的直接影响外，这些介质还参与炎症反应。T细胞的激活被发现与疾病的严重程度相关[1]。过敏性哮喘患者的支气管肺泡灌洗液和支气管活检组织中的CD4+T细胞显示，与对照组相比，Th2活性增加[2，3]。Th2来源的细胞因子IL-4、IL-5和IL-13可能在过敏性哮喘的病理生理过程中发挥关键作用，因为它们刺激B细胞IgE的产生和嗜酸性粒细胞的功能。CD8+T淋巴细胞可能通过产生大量的干扰素-γ发挥抑制性调节功能，从而抑制免疫球蛋白的产生[4]。T细胞反应在体内是如何调节的还不清楚。可能，抗原提呈细胞扮演着重要角色[5]。另一方面，肥大细胞产生大量的免疫调节细胞因子，在变态反应性炎症中可能具有重要的免疫调节功能。我们在这里展示了人类肥大细胞系HMC-1影响CD8+T细胞的特性。
Introduction In patients with allergic asthma, both mast cells and T lymphocytes are believed to be involved in the airway path-ophysiological processes. Cross-linking of mast cell IgE receptors by allergen binding leads to subsequent release of mediators. In addition to the immediate effects on broncho-constriction, these mediators also participate in inflammatory reactions. Activation of T cells was found to be correlated with disease severity [1]. CD4+ T cells from bron-choalveolar lavage fluid and bronchial biopsies from subjects with allergic asthma showed increased Th2 activity as compared to control subjects [2, 3]. The Th2-derived cytokines IL-4, IL-5 and IL-13 may play a pivotal role in the pathophysiology of allergic asthma in that they stimulate B cell IgE production and eosinophil functions. CD8+ T lymphocytes may exert suppressive regulatory functions by the production of substantial amounts of IFN-γ, resulting in the inhibition of IgE production [4]. How T cell reactions are regulated in vivo is unclear. Probably, antigenpresenting cells play an important role [5]. On the other hand, mast cells produce a large number of immunomodulatory cytokines and may have important immunoregulatory functions in allergic inflammation. We show here that the human mast cell line HMC-1 influences properties of CD8+ T cells.