Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors.
Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors.
复制标题
胆囊收缩素引起的饱腹感取决于 5-HT1C 受体的激活。
DOI：
10.1152/ajpregu.1993.264.1.r62
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Smith,GP
中科院分区：
文献类型：
--
作者：
Poeschla,B;Gibbs,J;Simansky,KJ;Greenberg,D;Smith,GP
为探讨大鼠饱腹作用与5-羟色胺能神经功能的关系，我们观察了不同5-羟色胺受体亚型选择性的5-羟色胺(5-HT)拮抗剂对全身注射八肽缩胆囊素(CCK-8)引起的摄食抑制的影响。5-HT1C/2选择性拮抗剂米安色林显著减弱CCK-8的饱足作用。然而，5-HT2拮抗剂酮色林和3种5-HT3拮抗剂MDL-72222、ICS205-930和恩丹西酮对CCK-8的饱腹作用无影响。这些结果表明，外源性CCK的饱足作用依赖于5-HT1(可能是5-HT1C)受体的激活，而不需要5-HT2或5-HT3受体的激活。
To investigate the dependence of the satiating action of cholecystokinin on serotonergic function in rats, we examined the effects of systemic pretreatment with serotonin (5-HT) antagonists of varying selectivity for 5-HT receptor subtypes on suppression of food intake induced by systemic administration of cholecystokinin octapeptide (CCK-8). Mianserin, a 5-HT1C/2-selective antagonist, significantly attenuated the satiating action of CCK-8. Ketanserin, a 5-HT2 antagonist, and three 5-HT3 antagonists, MDL-72222, ICS 205-930, and ondansetron, however, had no effect on the satiating action of CCK-8. These results demonstrate that the satiating action of exogenous CCK depends on activation of 5-HT1 (probably 5-HT1C) receptors and that activation of 5-HT2 or 5-HT3 receptors is not required.