EFFECTS OF GONADECTOMY AND EXOGENOUS GONADAL-STEROIDS ON SEX-DIFFERENCES IN OPEN-FIELD BEHAVIOR OF ADULT-RATS
EFFECTS OF GONADECTOMY AND EXOGENOUS GONADAL-STEROIDS ON SEX-DIFFERENCES IN OPEN-FIELD BEHAVIOR OF ADULT-RATS
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DOI：
10.1016/0166-4328(81)90017-6
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发表时间：
1981-01-01
影响因子：
2.7
通讯作者：
VANSTOLK, MA
中科院分区：
文献类型：
--
作者：
SLOB, AK;BOGERS, H;VANSTOLK, MA
本研究通过两个实验探讨了性腺激素对成年雌性和雄性大鼠旷场行为性别差异表达的贡献。第一组大鼠在成年后切除性腺或假手术，并在1、2、3、4、5或6周后在旷场进行测试（在白天的光照期内连续3天，每只大鼠3分钟）。性腺切除术后，公知的性别差异，在american和饲养行为（女性比男性多），以及排便（女性比男性少）仍然存在。卵巢切除术引起的american和饲养减少，排便增加。阉割对排便和直立没有显著影响，但也增加了排便。整体增加的american和饲养被发现：动物测试5和6周后的操作是显着更活跃的动物在1-4周后的操作。在第二个实验中，雌性和雄性大鼠被切除性腺，7周后，它们接受含有睾酮（T）、双氢睾酮（DHT）、雌二醇（E2）、DHT + E2的硅橡胶植入物，或不接受（对照条件）。植入后四周，在开放视野中测试动物（3分钟/大鼠，连续3天）。在排便（女性多于男性）和排便（女性少于男性）方面存在总体性别差异。唯一的激素效应是在DHT处理的动物中发现的：与其他激素和对照动物相比，最低的排便量和最高的排便量。在T、E2、DHT + E2和对照动物之间未发现差异。内源性性腺类固醇激素似乎在大鼠成年旷场行为的性别差异表达中起次要作用。
Two experiments were carried out to investigate the contribution of gonadal hormones to the expression of sex differences in open field behavior of adult female and male rats. In the 1st experiment rats were gonadectomized or sham-operated in adulthood and tested in the open field 1, 2, 3, 4, 5 or 6 wk later (3 min/rat on 3 consecutive days during the light period of the day). Following gonadectomy the well known sex difference in ambulation and rearing behavior (females more than males), as well as in defecation (females less than males) remained. Ovariectomy caused a decrease in ambulation and rearing, with an increase in defecation. Castration had no significant effect on ambulation and rearing, but also increased defecation. An overall increase in ambulation and rearing was found: animals tested 5 and 6 wk following the operation were significantly more active than animals tested at 1-4 wk after the operation. In the 2nd experiment female and male rats were gonadectomized and 7 wk later they received a silastic implant containing testosterone (T), dihydrotestosterone (DHT), estradiol (E2), DHT plus E2, or nothing (control condition). Four weeks after the implantation the animals were tested in the open field (3 min/rat on 3 consecutive days). An overall sex difference was found for ambulation (females more than males) and for defecation (females less than males). The only hormone effect was found in DHT-treated animals: lowest ambulation and highest defecation compared to other hormone and control animals. No differences were found between the T, E2, DHT plus E2, and control animals. Endogenous gonadal steroids seem to play a minor role in the expression of sex differences in adult open field behavior in the rat.