Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI).
Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI).
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DOI：
10.1016/j.neuroimage.2008.12.072
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发表时间：
2009-05-01
期刊：
影响因子：
5.7
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Langbaum JB;Chen K;Lee W;Reschke C;Bandy D;Fleisher AS;Alexander GE;Foster NL;Weiner MW;Koeppe RA;Jagust WJ;Reiman EM;Alzheimer's Disease Neuroimaging Initiative
在大多数小型单中心研究中，阿尔茨海默病（AD）与局部脑葡萄糖代谢率（CMRgl）的氟脱氧葡萄糖正电子发射断层扫描（PET）测量的特征性和进行性降低相关。AD神经影像学倡议（ADNI）正在一项大型纵向多中心研究中获取FDG PET、体积磁共振成像和其他生物标志物测量结果，该研究包括最初轻度受累的可能AD（pAD）患者、AD风险增加的遗忘型轻度认知障碍（aMCI）患者和认知正常对照（NC），我们负责使用统计参数映射（SPM）分析PET图像。在这里，我们比较了74名pAD患者和142名aMCI患者与82名NC患者的基线CMRgl测量值，我们将CMRgl与临床疾病严重程度的分类和连续测量值相关联，并且我们比较了这些受试者组中每个受试者组的载脂蛋白E（APOE）ε4携带者与非携带者。与NC相比，pAD和aMCI组各自在后扣带回、楔前叶、顶叶颞叶和额叶皮质中双侧具有显著较低的CMRgl。当疾病严重程度的类别或较低的简易精神状态检查（MMSE）评分与较低的CMRgl相关时，观察到类似的降低。然而，当分析仅限于pAD患者时，较低的MMSE评分与左额叶下部和颞叶CMRgl显著相关。来自大型多中心研究的这些发现支持先前的单中心发现，支持AD和aMCI患者中基线CMRgl降低的特征模式，以及AD痴呆发作后优先前部CMRgl降低。
In mostly small single-center studies, Alzheimer’s disease (AD) is associated with characteristic and progressive reductions in fluorodeoxyglucose positron emission tomography (PET) measurements of the regional cerebral metabolic rate for glucose (CMRgl). The AD Neuroimaging Initiative (ADNI) is acquiring FDG PET, volumetric magnetic resonance imaging, and other biomarker measurements in a large longitudinal multi-center study of initially mildly affected probable AD (pAD) patients, amnestic mild cognitive impairment (aMCI) patients, who are at increased AD risk, and cognitively normal controls (NC), and we are responsible for analyzing the PET images using statistical parametric mapping (SPM). Here we compare baseline CMRgl measurements from 74 pAD patients and 142 aMCI patients to those from 82 NC, we correlate CMRgl with categorical and continuous measures of clinical disease severity, and we compare apolipoprotein E (APOE) ε4 carriers to non-carriers in each of these subject groups. In comparison with NC, the pAD and aMCI groups each had significantly lower CMRgl bilaterally in posterior cingulate, precuneus, parietotemporal and frontal cortex. Similar reductions were observed when categories of disease severity or lower Mini-Mental State Exam (MMSE) scores were correlated with lower CMRgl. However, when analyses were restricted to the pAD patients, lower MMSE scores were significantly correlated with lower left frontal and temporal CMRgl. These findings from a large, multi-site study support previous single-site findings, supports the characteristic pattern of baseline CMRgl reductions in AD and aMCI patients, as well as preferential anterior CMRgl reductions after the onset of AD dementia.
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