Nonalcoholic Fatty Liver Disease in Prepubertal Children Born Small for Gestational Age: Influence of Rapid Weight Catch-Up Growth
Nonalcoholic Fatty Liver Disease in Prepubertal Children Born Small for Gestational Age: Influence of Rapid Weight Catch-Up Growth
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DOI：
10.1159/000347217
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发表时间：
2013-01-01
影响因子：
3.2
通讯作者：
Cavallo, Luciano
中科院分区：
文献类型：
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作者：
Faienza, Maria Felicia;Brunetti, Giacomina;Cavallo, Luciano
背景/目的：我们研究了低出生体重与超声评估的非酒精性脂肪性肝病(NAFLD)的关系，以检验以下假设：胎儿生长迟缓和体重快速增长可能是通过胰岛素抵抗(IR)和/或腹内脂肪导致肝脏脂肪变性的另一个因素。方法：入选23例出生后6~12个月快速追赶生长的小于胎龄儿(SGA)和24例正常胎龄儿(AGA)作为对照。所有儿童都接受了人体测量、身体成分测量和肝功能测试、血脂、血糖和胰岛素水平的评估。腹部超声检查以评估肝脏脂肪变性及皮下和内脏脂肪组织厚度。结果：23例SGA患儿中有8例(34.8%)出现NAFLD。有肝脂肪变性的儿童IR和内脏脂肪显著高于无脂肪变性的儿童。IR指数与肝脏脂肪变性显著相关，与体重指数标准差积分和内脏脂肪无关。结论：对于出生后体重快速增加的SGA青春期前儿童，NAFLD应被认为是一个新出现的问题，IR起着关键作用。孕期和出生第一年的适当饮食可能会预防这些受试者的代谢综合征和非酒精性脂肪肝。版权所有(C)2013 S.Karger AG，巴塞尔
Background/Aims: We studied the association of low birth weight with ultrasound-assessed nonalcoholic fatty liver disease (NAFLD) to test the hypothesis that fetal growth retardation followed by a rapid weight catch-up growth might be an additional factor responsible for liver steatosis via insulin resistance (IR) and/or intra-abdominal fat. Methods: We enrolled 23 children born small for gestational age (SGA) with a rapid catch-up growth within the first 6-12 months, and 24 appropriate for gestational age (AGA) children as controls. All children underwent anthropometric, body composition measurements and evaluation of liver function tests, lipid profile, plasma glucose and insulin levels. Abdominal ultrasonography was performed in order to asses liver steatosis and thickness of subcutaneous and visceral adipose tissue. Results: NAFLD were observed in 8 out of the 23 SGA children (34.8%). IR and visceral fat were significantly increased in children with hepatic steatosis compared to those without. IR index was significantly related to liver steatosis, independently of body mass index standard deviation score and visceral fat. Conclusions: NAFLD should be recognized as an emerging problem in SGA prepubertal children who presented a rapid weight gain in postnatal life, and IR plays the key role. An appropriate diet during pregnancy and in the first year of life might prevent metabolic syndrome and NAFLD in these subjects. Copyright (C) 2013 S. Karger AG, Basel