Increased chromosome translocations and aneuploidy in peripheral blood lymphocytes of patients having revision arthroplasty of the hip
Increased chromosome translocations and aneuploidy in peripheral blood lymphocytes of patients having revision arthroplasty of the hip
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DOI：
10.1302/0301-620x.83b7.10102
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发表时间：
2001-09-01
影响因子：
--
通讯作者：
Case, CP
中科院分区：
文献类型：
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作者：
Doherty, AT;Howell, RT;Case, CP
磨屑的长期生物学效应尚不清楚。我们研究了是否有任何证据表明，在外周血淋巴细胞的累积致突变损伤的患者进行翻修关节置换术的主要金属对塑料全髋关节置换术相比，在初次arthroplasty.There是一个非整倍体增加了三倍，染色体易位增加了两倍，这不能解释的混杂变量吸烟，性别，年龄和诊断X光片。在使用TiVaAl假体的患者中，非整倍体增加了5倍，但染色体易位没有增加。相比之下，在钴铬合金假体的患者中，非整倍体增加了2.5倍，染色体易位增加了3.5倍。在6例不锈钢假体的患者中，非整倍体或染色体易位没有增加，我们的研究结果表明，未来的流行病学研究的假定长期风险的关节置换术应考虑到在假体中使用的合金类型。
The long-term biological effects of wear debris are unknown. We have investigated whether there is any evidence of cumulative mutagenic damage in peripheral blood lymphocytes of patients undergoing revision arthroplasty of predominantly metal-on-plastic total hip replacements compared with those at primary arthroplasty.There was a threefold increase in aneuploidy and a twofold increase in chromosomal translocations which could not be explained by the confounding variables of smoking, gender, age and diagnostic radiographs. In the patients with TiVaAl prostheses there was a fivefold increase in aneuploidy but no increase in chromosomal translocations. By contrast, in patients with cobalt-chrome prostheses there was a 2.5-fold increase in aneuploidy and a 3.5-fold increase in chromosomal translocations. In six patients with stainless-steel prostheses there was no increase in either aneuploidy or chromosomal translocations.Our results suggest that future epidemiological studies of the putative long-term risks of joint replacement should take into account the type of alloy used in the prosthesis.