Synthesis of metal-chelating lipids to sensitize lanthanide ions.
Synthesis of metal-chelating lipids to sensitize lanthanide ions.
复制标题
合成金属螯合脂质以敏化镧系离子。
DOI：
10.1021/jo026833k
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Campiglia,AndresD
中科院分区：
文献类型：
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作者：
Roy,BidhanC;Santos,Marina;Mallik,Sanku;Campiglia,AndresD
Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid18-Eu3+provided a probe that relies not only on the emission wavelengths of Eu3+but also on a reproducible lifetime that can be used for protein identification.
