Do extremely low frequency magnetic fields enhance the effects of environmental carcinogens? A meta-analysis of experimental studies
Do extremely low frequency magnetic fields enhance the effects of environmental carcinogens? A meta-analysis of experimental studies
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DOI：
10.1080/09553000600577839
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Naarala, J
中科院分区：
文献类型：
--
作者：
Juutilainen, J;Kumlin, T;Naarala, J
目的：本文是对体外研究和短期动物研究数据的荟萃分析，这些研究将极低频磁场与已知致癌物或其他有毒物理或化学物质相结合。材料和方法：通过系统比较阳性和阴性研究之间的研究特征来分析数据，以揭示可能的一致模式。大多数研究都是积极的，表明磁场确实与其他化学和物理暴露相互作用。发表偏倚不太可能解释这些发现。有趣的是，一个非线性的“剂量反应”被发现，显示在1和3 mT之间的领域的积极研究的最小百分比。自由基对机制（磁场对重组的自由基对的影响）是一个很好的候选机制，用于解释在本analysis.Conclusions中看到的双相剂量反应：大多数研究回顾使用磁场100亩T或更高，所以研究结果是没有直接相关的流行病学调查结果表明，儿童白血病的风险增加0.4亩T以上的解释。然而，即使在100 μ T下确认的不利影响也会对风险评估和管理产生影响，包括需要重新考虑磁场的暴露限值。显然需要进一步研究磁场的综合效应。
Purpose: This paper is a meta-analysis of data from in vitro studies and short-term animal studies that have combined extremely low frequency magnetic fields with known carcinogens or other toxic physical or chemical agents.Materials and methods: The data was analyzed by systematic comparison of study characteristics between positive and negative studies to reveal possible consistent patterns.Results: The majority of the studies reviewed were positive, suggesting that magnetic fields do interact with other chemical and physical exposures. Publication bias is unlikely to explain the findings. Interestingly, a nonlinear 'dose-response' was found, showing a minimum percentage of positive studies at fields between 1 and 3 mT. The radical pair mechanism (magnetic field effects on recombination of radical pairs) is a good candidate mechanism for explaining the biphasic dose-response seen in the present analysis.Conclusions: Most of the studies reviewed used magnetic fields of 100 mu T or higher, so the findings are not directly relevant for explaining the epidemiological findings suggesting increased risk of childhood leukemia above 0.4 mu T. However, confirmed adverse effects even at 100 mu T would have implications for risk assessment and management, including the need to reconsider the exposure limits for magnetic fields. There is an obvious need for further studies on combined effects with magnetic fields.