Genetic influences on changes in body bass index: A longitudinal analysis of women twins.
Genetic influences on changes in body bass index: A longitudinal analysis of women twins.
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DOI：
10.1002/j.1550-8528.1997.tb00559.x
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发表时间：
1997-07-01
期刊：
影响因子：
--
通讯作者：
King, MC
中科院分区：
文献类型：
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作者：
Austin, MA;Friedlander, Y;King, MC
许多研究已经证明了遗传对体脂的影响，但也可能对其个体内随时间变化的遗传效应。这项研究使用来自Kaiser Permanente女性双胞胎研究的两次检查的纵向数据来检验身体质量指数的变化，这两次检查相隔十年进行。分析包括630名女性，185对同卵双胞胎和130对异卵双胞胎，在两次检查中平均年龄分别为41岁和51岁。使用三种不同的统计分析方法，对十年来体重指数变化的年龄调整遗传率估计在0.57%到0.86%之间(均P均小于或等于0.001)，表明至少一半，在多基因模型下，BMI变化的方差可能高达85%可归因于遗传影响，在对环境因素(范围从0.57到0.78)进行调整和对基线上的BMI进行额外调整(从0.41到0.79)之后，这些估计值仍然具有统计学意义，尽管这些调整后双合子组内相关性很低。因此，除了已知的环境和行为影响外，这些结果还为十年来女性BMI变化的遗传影响提供了证据。
Numerous studies have demonstrated genetic influences on body fat, but there also may be genetic effects on its intraindividual variation over time, This study examined changes in body mass index (BMI) using longitudinal data from two examinations of the Kaiser Permanente Women Twins Study, performed a decade apart, The analysis included 630 women, 185 monozygotic and 130 dizygotic twin pairs, with average ages of 41 years and 51 years at the two examinations, respectively, Age-adjusted heritability estimates for the change in BMI over the decade ranged from 0.57 to 0.86 (all p less than or equal to 0.001) using three different statistical analysis approaches, indicating that at least half, and possibly as much as 85%, of the variance in the change in BMI is attributable to genetic influences under a polygenic model, These estimates remained statistically significant after adjusting for environmental factors (ranging from 0.57 to 0.78) and with additional adjustment for BMI at baseline (ranging from 0.41 to 0.79), although dizygotic intraclass correlations were low after these adjustments. Thus, in addition to known environmental and behavioral influences, these results provide evidence for genetic influences on changes in BMI over a decade in women.