NONSPECIFIC INTERSTITIAL PNEUMONIA/FIBROSIS - HISTOLOGIC FEATURES AND CLINICAL-SIGNIFICANCE
NONSPECIFIC INTERSTITIAL PNEUMONIA/FIBROSIS - HISTOLOGIC FEATURES AND CLINICAL-SIGNIFICANCE
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DOI：
10.1097/00000478-199402000-00003
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发表时间：
1994-02-01
影响因子：
5.6
通讯作者：
FIORELLI, RF
中科院分区：
文献类型：
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作者：
KATZENSTEIN, ALA;FIORELLI, RF
确定了 64 例间质性肺炎病例，这些病例不能归入特发性间质性肺炎的三个主要类别之一。这些病例被描述性地称为非特异性间质性肺炎/纤维化，其特征是不同比例的间质性炎症和纤维化，似乎在单一时间跨度内发生（即，该过程在时间上是一致的）。最常见的主诉是几个月的呼吸困难，胸片通常显示双侧间质浸润。预后良好，在已知随访的 48 名患者中，仅有 5 名患者因进行性呼吸道疾病死亡 (11%)。活检显示纯粹炎症且无纤维化的患者没有死亡。由于预后更好且治疗方案不同，非特异性间质性肺炎必须与特发性间质性肺炎的三种主要形式分开。然而，它不应被视为一种特定疾病，因为它可能有不同的病因，包括潜在的结缔组织疾病、有机粉尘或其他暴露以及既往急性肺损伤；少数情况下，它可能反映另一个过程的非代表性活检。
Sixty-four cases of interstitial pneumonia were identified that could not be classified into one of three main categories of idiopathic interstitial pneumonia. These cases, descriptively termed nonspecific interstitial pneumonia/fibrosis, were characterized by varying proportions of interstitial inflammation and fibrosis that appeared to be occurring over a single time span (i.e., the process was temporally uniform.) The most common presenting complaint was dyspnea for several months, and chest radiographs usually showed bilateral interstitial infiltrates. The prognosis was good with only five deaths due to progressive respiratory disease in 48 patients with known follow-up (11%). No deaths occurred in patients whose biopsies showed pure inflammation and no fibrosis. Nonspecific interstitial pneumonia must be separated from the three main forms of idiopathic interstitial pneumonia because of better prognosis and different treatment options. It should not be considered a specific disease, however, because it may have varying etiologies including underlying connective tissue diseases, organic dust or other exposures, and prior acute lung injury; less often, it may reflect a nonrepresentative biopsy of another process.