Younger age negatively impacts depression-associated exacerbation of hemoglobin A1c levels in type 2 diabetes: Implications for intervention.
Younger age negatively impacts depression-associated exacerbation of hemoglobin A1c levels in type 2 diabetes: Implications for intervention.
复制标题
年龄较小对 2 型糖尿病患者抑郁相关的糖化血红蛋白水平恶化有负面影响：干预的意义。
DOI：
10.1002/smi.2904
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ajilore,OlusolaA
中科院分区：
文献类型：
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作者：
Jean,Moïse-DenisK;Mihailescu,DanV;Ajilore,Olugbenga;Kumar,Anand;Ajilore,OlusolaA
与非抑郁症患者相比，患有2型糖尿病（T2 DM）和抑郁症的成年人与较高的糖化血红蛋白（HbA 1C）相关。关于导致这些差异的相关临床和人口统计学成分知之甚少。我们研究了伴有和不伴有抑郁症的T2 DM成人患者之间HbA 1C的差异，T检验和卡方分析测量了HbA 1C和临床/人口统计学变量的差异。与非抑郁参与者相比，抑郁参与者的HbA 1C在统计学上更高。在控制年龄后，差异不再具有统计学意义。年龄和HbA 1C在整个样本中呈负相关，并且在每个组中仍然独立相关。年龄与HbA 1C的交互作用受抑郁状态的调节。此外，使用适度分析和Blinder-瓦哈卡分解技术评估了糖尿病严重程度差异的机制。抑郁和非抑郁糖尿病参与者之间74%的平均结果HbA 1C差异可由年龄解释。此外，年龄与舒张压和胆固醇等临床变量呈负相关。比较吸烟和不吸烟参与者的年龄，吸烟者在统计学上更年轻。年轻的T2 DM患者可能需要更多关注自我管理，特别是在抑郁症的背景下。抑郁症应筛查和治疗糖尿病患者，因为这加剧了糖尿病的严重程度。
Adults with type 2 diabetes (T2DM) and depression are associated with higher hemoglobin A1C(HbA1C) compared to their nondepressed counterparts. Little is known about related clinical and demographic components contributing to these differences. We examined differences in HbA1Cbetween adults who have T2DM with and without major depression.Ttests and chi‐square analyses measured differences in HbA1Cand clinical/demographic variables. HbA1Cwas statistically higher in depressed participants compared to nondepressed participants. The difference was no longer statistically significant after controlling for age. Age and HbA1Cwere negatively correlated across the sample and were still correlated in each group independently. The interaction of age and HbA1Cwas moderated by depression status. Additionally, mechanisms for diabetes severity differences were assessed using moderation analyses and Blinder‐Oaxaca decomposition technique. Seventy‐four percent of the mean outcome HbA1Cdifference between depressed and nondepressed diabetic participants was explained by age. Furthermore, age was negatively correlated with clinical variables, such as diastolic blood pressure and cholesterol. Comparing age to smoking and nonsmoking participants, smokers were statistically younger. Younger adults with T2DM may require more attention regarding self‐management, particularly in the context of depression. Depression should be screened and treated among individuals with diabetes since this exacerbates diabetes severity.