Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration.
Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration.
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DOI：
10.2147/opth.s120402
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Ogura Y
中科院分区：
文献类型：
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作者：
Suetsugu T;Kato A;Yoshida M;Yasukawa T;Nishiwaki A;Hasegawa N;Usui H;Ogura Y
我们的目的是利用宽视场成像仪器评估湿性年龄相关性黄斑变性（AMD）中异常周围眼底自身荧光（FAF）的患病率。对46例日本湿性AMD患者66只眼和20例对照患者32只眼进行回顾性病例对照研究。典型AMD（37眼/28例）、息肉样脉络膜血管病变（PCV）（22眼/20例）和视网膜血管瘤增生（RAP）（7眼/ 4例）获得广角FAF图像。两位蒙面眼科医生独立地对图像进行了斑驳、颗粒和数字模式的分级。主要观察指标为外周FAF异常频率和疾病亚组及治疗的相对危险度。湿性AMD眼外周FAF异常发生率为51.5%，对照组为18.8% （P<0.001）。湿性黄斑变性眼的斑驳型、粒状型和数字型分别占45.5%、31.8%和16.7%。各疾病亚组（典型AMD， 54.1%， PCV, 36.4%， RAP, 85.7%）外周血FAF发生率均显著高于对照眼（18.8%）（P<0.001， P=0.03， P<0.001）。未治疗组和治疗组的频率无显著差异（P=0.76）。日本湿性AMD患者眼FAF异常发生率高于对照眼。在三种疾病亚型中，异常模式在PCV眼中最不常见。
We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments. Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (P<0.001, P=0.03, and P<0.001, respectively) than control eyes (18.8%). There were no significant differences (P=0.76) between the frequencies in untreated and treated eyes. Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes.