Pulmonary interstitial resistance.
Pulmonary interstitial resistance.
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肺间质阻力。
DOI：
10.1007/bf02364052
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发表时间：
1987
影响因子：
3.8
通讯作者：
Conhaim,RL
中科院分区：
文献类型：
--
作者：
Lai-Fook,SJ;Conhaim,RL
围绕大肺血管的血管周围间质的机械特性是根据间质流体压力、间质顺应性和间质液压阻力来定义的。间隙压力是决定液体穿过微血管屏障的过滤的主要力量之一。间质顺应性是间质因水合作用而膨胀的能力的量度，这增加了间质压力并降低了过滤速率。间质压力和顺应性是周围肺实质和血管壁的弹性特性的函数。固体连续介质力学用于描述肺实质的行为。间质的传输特性用多孔材料来描述，多孔材料的流体阻力由渗透率常数决定。间质液的动力学由流动与弹性环境的耦合控制。开发了电模拟模型来预测水肿形成过程中间质液袖带的增长。
The mechanical properties of the perivascular interstitium surrounding large pulmonary blood vessels are defined in terms of interstitial fluid pressure, interstitial compliance, and interstitial hydraulic resistance. Interstitial pressure is one of the main forces which determine liquid filtration across the microvascular barrier. Interstitial compliance is a measure of the ability of the interstitium to swell with hydration which increases interstitial pressure and reduces the filtration rate. Interstitial pressure and compliance are functions of the elastic properties of the surrounding lung parenchyma and the vessel wall. Solid continuum mechanics are used to describe the behavior of the lung parenchyma. The transport properties of the interstitium are described in terms of a porous material whose fluid resistance is determined by a permeability constant. The dynamics of interstitial fluid are governed by the coupling of the flow with the elastic environment. An electrical analog model is developed to predict the growth of interstitial fluid cuffs during edema formation.