The selective serotonin reuptake inhibitor paroxetine does not alter consummatory concentration-dependent licking of prototypical taste stimuli by rats.
The selective serotonin reuptake inhibitor paroxetine does not alter consummatory concentration-dependent licking of prototypical taste stimuli by rats.
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DOI：
10.1093/chemse/bjr011
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发表时间：
2011-07
期刊：
影响因子：
3.5
通讯作者：
C. Mathes;A. Spector
中科院分区：
文献类型：
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作者：
C. Mathes;A. Spector
5 -羟色胺和5HT（1A）受体在一部分味觉受体细胞中表达，5HT(3)受体在支配味蕾的传入纤维上表达。选择性5 -羟色胺再摄取抑制剂帕罗西汀的外源性管理已被证明可以增加人类对甜味和苦味刺激的味觉敏感性。5 -羟色胺能激动剂也能减少食物和液体的摄入量，并且5 -羟色胺的调节可能会改变基于味觉的享乐反应；另外，或者结合起来，血清素可能与生理状态相互作用，影响摄取行为。在这项研究中，在短暂接触味觉测试中，大鼠在给予帕罗西汀（0.3-10 mg/kg腹腔注射）后，对原型味觉刺激的无条件舔舐进行了评估。我们还测量了在帕罗西汀（5mg /kg）后不同剥夺状态下大鼠舔蔗糖的情况。在这两个实验中，我们都没有发现任何证据表明帕罗西汀在减少食物摄入量的剂量下，对舔舐相对于水的任何味觉刺激有影响。然而，在某些情况下，帕罗西汀减少了开始的试验。因此，通过帕罗西汀给药系统性地增加血清素可以减少短暂接触试验中的食欲行为，但不足以改变味觉引导的完成行为。
Serotonin and the 5HT(1A) receptor are expressed in a subset of taste receptor cells, and the 5HT(3) receptor is expressed on afferent fibers innervating taste buds. Exogenous administration of the selective serotonin reuptake inhibitor, paroxetine, has been shown to increase taste sensitivity to stimuli described by humans as sweet and bitter. Serotonergic agonists also decrease food and fluid intake, and it is possible that modulations of serotonin may alter taste-based hedonic responsiveness; alternatively, or in combination, serotonin may interact with physiological state to impact ingestive behavior. In this study, the unconditioned licking of prototypical taste stimuli by rats in brief-access taste tests was assessed following paroxetine administration (0.3-10 mg/kg intraperitoneal). We also measured sucrose licking by rats in different deprivation states after paroxetine (5 mg/kg). In neither experiment did we find any evidence of an effect of paroxetine on licking relative to water to any of the taste stimuli in the brief-access test at doses that decreased food intake. However, in some conditions, paroxetine decreased trials initiated to tastants. Therefore, a systemic increase in serotonin via paroxetine administration can decrease appetitive behavior in brief-access tests but is insufficient to alter taste-guided consummatory behavior.