A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress.
A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress.
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DOI：
10.1016/j.jneuroim.2017.10.017
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发表时间：
2017-12-15
影响因子：
3.3
通讯作者：
Weiss JM
中科院分区：
文献类型：
--
作者：
Jones HP;Aldridge B;Boss-Williams K;Weiss JM
Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells’ inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80+ molecule expression by B cells correlated with decreased tumor lysis and increased tumor development. Thus, tumor defenses in the lung given stress exposure can depend on the B cell function.
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