DAILY MICRONUTRIENT SUPPLEMENTS ENHANCE DELAYED-HYPERSENSITIVITY SKIN-TEST RESPONSES IN OLDER-PEOPLE
DAILY MICRONUTRIENT SUPPLEMENTS ENHANCE DELAYED-HYPERSENSITIVITY SKIN-TEST RESPONSES IN OLDER-PEOPLE
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DOI：
10.1093/ajcn/60.3.437
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发表时间：
1994-09-01
影响因子：
7.1
通讯作者：
LOURIA, DB
中科院分区：
文献类型：
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作者：
BOGDEN, JD;BENDICH, A;LOURIA, DB
进行了一项安慰剂对照双盲试验，研究每日微量营养素补充剂对循环维生素和微量金属浓度以及迟发型超敏反应（DHST）反应的影响。受试者，年龄59-85岁，随机分配到安慰剂（n = 27）或微量营养素（n = 29）治疗组。DHST和9种微量营养素的循环浓度进行了测量之前和之后6个月和12个月的微量营养素摄入。对于微量营养素组，在6个月和/或12个月时，抗坏血酸、β-胡萝卜素、叶酸、维生素B-6和α-生育酚的平均血清浓度有统计学显著性增加。在12个月时，安慰剂组中具有一个或多个低浓度的受试者数量显著增加。在12个月时，微量营养素组对一组7种回忆抗原的DHST反应显著增加，但安慰剂组没有。这项研究表明，每天补充低至中等剂量的微量营养素可以防止某些微量营养素的低浓度，并可以改善健康，独立生活的老年人的DHST反应。
A placebo-controlled double-blind trial of the effects of daily micronutrient supplements on circulating vitamin and trace metal concentrations and delayed-hypersensitivity skin test (DHST) responses was conducted. Subjects, aged 59-85 y, were randomly assigned to placebo (n = 27) or micronutrient (n = 29) treatment groups. DHST and circulating concentrations of nine micronutrients were measured before and after 6 and 12 mo of micronutrient ingestion. For the micronutrient group, there were statistically significant increases at 6 and/or 12 mo in the mean serum concentrations of ascorbate, beta-carotene, folate, vitamin B-6, and alpha-tocopherol. There was a significant increase at 12 mo in the number of subjects in the placebo group with one or more low concentrations. DHST responses to a panel of seven recall antigens were significantly increased at 12 mo in the micronutrient group but not the placebo group. This study demonstrates that daily supplementation with low-to-moderate doses of micronutrients can prevent low concentrations of some micronutrients and can improve DHST responses in healthy, independently living older adults.