Assessment of delay in age-appropriate vaccination using survival analysis
Assessment of delay in age-appropriate vaccination using survival analysis
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DOI：
10.1093/aje/kwj074
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发表时间：
2006-03-15
影响因子：
5
通讯作者：
Strebel, P
中科院分区：
文献类型：
--
作者：
Dayan, GH;Shaw, KM;Strebel, P
与最新的疫苗接种覆盖率相比，对适龄疫苗接种延迟的评估提供了更多关于疫苗接种及时性的信息。作者将生存分析方法应用于2002年在阿根廷进行的13-59个月儿童疫苗接种覆盖率调查的数据。到19个月大时，43%的儿童（95%置信区间（CI）：40，46）接种了第四剂白喉、破伤风和百日咳疫苗（DTP 4）。到13个月大时，55%的儿童（95% CI：52，57）接种了含麻疹疫苗。到7个月大时，33%的儿童（95% CI：27，40）接种了第三剂B型肝炎疫苗。与第一胎相比，第三胎更可能延迟DTP 4（相对危险度（RR）= 1.41，95% CI：1.22，1.62）、含麻疹疫苗（RR = 1.54，95% CI：1.32，1.78）和第三剂B肝炎（RR = 1.31，95% CI：1.03，1.67）。与未完成小学教育的儿童相比，照顾者完成中学教育的儿童不太可能延迟DTP 4（RR = 0.68，95%CI：0.52，0.90）。生存分析方法有助于衡量疫苗的吸收，并应考虑在未来的调查时，评估年龄适当的疫苗接种延迟。
Assessment of delay in age-appropriate vaccination provides more information about timeliness of vaccination than up-to-date vaccination coverage. The authors applied survival analysis methods to data from a vaccination coverage survey among children aged 13-59 months conducted in Argentina in 2002. By age 19 months, 43% of children (95% confidence interval (CI): 40, 46) were vaccinated with the fourth dose of diphtheria, tetanus, and pertussis (DTP4). By age 13 months, 55% of children (95% CI: 52, 57) were vaccinated with measles-containing vaccine. By age 7 months, 33% of children (95% CI: 27, 40) were vaccinated with the third dose of hepatitis B. Compared with firstborn children, third children were more likely to be delayed for DTP4 (relative risk (RR) = 1.41, 95% CI: 1.22, 1.62), measles-containing vaccine (RR = 1.54, 95% CI: 1.32, 1.78), and the third dose of hepatitis B (RR = 1.31, 95% CI: 1.03, 1.67). Children whose caregivers had completed secondary school were less likely to be delayed for DTP4 (RR = 0.68, 95% CI: 0.52, 0.90) compared with those whose caregivers had not completed primary school. Survival analysis methods were helpful in measuring vaccine uptake and should be considered in future surveys when assessing delay in age-appropriate vaccination.