Vascularization of three-dimensional engineered tissues for regenerative medicine applications.
Vascularization of three-dimensional engineered tissues for regenerative medicine applications.
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DOI：
10.1016/j.actbio.2016.06.001
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发表时间：
2016-09-01
影响因子：
9.7
通讯作者：
Huang NF
中科院分区：
文献类型：
--
作者：
Kim JJ;Hou L;Huang NF
三维组织工程是修复病变或功能失调心肌的一种很有前途的方法。然而，该领域的一个主要瓶颈是缺乏有效的血管化策略，因为体外生产的组织结构需要持续的氧气和营养流动来维持活力和功能。与血管生成细胞治疗和生长因子治疗相比，生物工程方法，如空间微图案、牺牲材料、组织脱细胞和3D生物打印，能够产生更精确可控的新血管形成。在这篇综述中，我们总结了开发具有血管系统的3D组织工程结构的最新方法，并展示了这些技术如何应用于治疗心力衰竭的再生医学。
Engineering of three-dimensional (3D) tissues is a promising approach for restoring diseased or dysfunctional myocardium with a functional replacement. However, a major bottleneck in this field is the lack of efficient vascularization strategies, because tissue constructs produced in vitro require a constant flow of oxygen and nutrients to maintain viability and functionality. Compared to angiogenic cell therapy and growth factor treatment, bioengineering approaches such as spatial micropatterning, sacrificial materials, tissue decellularization, and 3D bioprinting enable the generation of more precisely controllable neovessel formation. In this review, we summarize the state-of-the-art approaches to develop 3D tissue engineered constructs with vasculature, and demonstrate how some of these techniques have been applied towards regenerative medicine for treatment of heart failure.