Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation
Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation
复制标题
使用经颅聚焦超声刺激操纵灵长类动物大脑的皮层下和深层皮层活动
DOI：
10.1101/342303
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Folloni D
中科院分区：
文献类型：
--
作者：
Folloni D
神经网络中某个区域的因果作用可以通过干扰其活动并测量其影响来确定。目前许多可逆的操作技术有限制，阻止其应用，特别是在灵长类动物大脑的深部区域。在这里，我们证明了一个集中的经颅超声刺激（TUS）协议的影响活动，甚至在大脑深部区域：皮质下的大脑结构，杏仁核（实验1），和一个深层皮质区，前扣带皮层（ACC，实验2），在猕猴。TUS的神经调节作用通过使用功能性磁共振成像（fMRI）检查每个区域与大脑其他区域的活动之间的关系来测量。在没有超声处理的对照条件下，给定区域中的活性与互连区域中的活性相关，但这种关系在超声处理后降低，特别是对于靶向区域。对神经活动的分离和聚焦效应不能用听觉混淆来解释。
The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas of the primate brain. Here, we demonstrate that a focused transcranial ultrasound stimulation (TUS) protocol impacts activity even in deep brain areas: a subcortical brain structure, the amygdala (experiment 1), and a deep cortical region, the anterior cingulate cortex (ACC, experiment 2), in macaques. TUS neuromodulatory effects were measured by examining relationships between activity in each area and the rest of the brain using functional magnetic resonance imaging (fMRI). In control conditions without sonication, activity in a given area is related to activity in interconnected regions, but such relationships are reduced after sonication, specifically for the targeted areas. Dissociable and focal effects on neural activity could not be explained by auditory confounds.