Bromodomain-Containing Protein 4: A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix.
Bromodomain-Containing Protein 4: A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix.
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DOI：
10.1155/2012/670632
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发表时间：
2012
影响因子：
1.9
通讯作者：
Hunter KW
中科院分区：
文献类型：
--
作者：
Alsarraj J;Hunter KW
转移是一个极其复杂的过程，是大多数癌症相关死亡的原因。恶性原发性肿瘤可以通过手术切除，但在远处器官迁移、侵入和增殖的细胞通常是最难治疗的细胞。越来越多的证据表明，原发肿瘤外的宿主因素在转移的发展中具有重要意义。最近，我们已经表明含溴结构域蛋白4或溴结构域4（Brd4）作为乳腺癌进展和转移的遗传易感基因发挥作用。在本文中，我们将讨论宿主的遗传背景，肿瘤的出现可以显着改变随后的转移性疾病的生物学，我们将集中在调节转移易感性的Brd4的作用。
Metastasis is an extremely complex process that accounts for most cancer-related deaths. Malignant primary tumors can be removed surgically, but the cells that migrate, invade, and proliferate at distant organs are often the cells that prove most difficult to target therapeutically. There is growing evidence that host factors outside of the primary tumors are of major importance in the development of metastasis. Recently, we have shown that the bromodomain-containing protein 4 or bromodomain 4 (Brd4) functions as an inherited susceptibility gene for breast cancer progression and metastasis. In this paper, we will discuss that host genetic background on which a tumor arises can significantly alter the biology of the subsequent metastatic disease, and we will focus on the role of Brd4 in regulating metastasis susceptibility.