AgF-Mediated Fluorinative Homocoupling of gem-Difluoroalkenes
AgF-Mediated Fluorinative Homocoupling of gem-Difluoroalkenes
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AgF 介导的偕二氟烯烃的氟化均偶联
DOI：
10.1021/ol403083e
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发表时间：
2014-01-03
期刊：
影响因子：
5.2
通讯作者：
Hu, Jinbo
中科院分区：
文献类型：
--
作者：
Gao, Bing;Zhao, Yanchuan;Hu, Jinbo
描述了一种新型氟化银介导的 β,β-二氟苯乙烯衍生物的自偶联反应。该转化是通过氟化银 (I) 与 β,β-二氟苯乙烯的亲核加成引发的，然后是相应的苄基银中间体的二聚化。该反应显示出良好的底物范围和官能团耐受性，并且代表了有关（α-三氟甲基）苄基银物质反应性的第一份报告。
A novel silver(I)-fluoride-mediated homocoupling reaction of beta,beta-difluorostyrene derivatives is described. The transformation is initiated via nucleophilic addition of silver(I) fluoride to beta,beta-difluorostyrenes, which is followed by dimerization of the corresponding benzylsilver intermediates. The reaction shows good substrate scope, functional group tolerance, and represents the first report on the reactivity of (alpha-trifluoromethyl)benzylsilver species.