Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls
Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls
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DOI：
10.1016/s0140-6736(08)60167-1
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发表时间：
2008-01-01
期刊：
影响因子：
168.9
通讯作者：
Risch, H. A.
中科院分区：
文献类型：
--
作者：
Beral, V.;Doll, R.;Risch, H. A.
背景口服避孕药是在近50年前推出的，目前有超过1亿妇女在使用它们。口服避孕药可以降低患卵巢癌的风险，但这种减少最终对公共健康的影响将取决于这种保护在停止使用后持续多长时间。方法对21个国家和地区的45项流行病学研究中23257例卵巢癌患者(病例组)和87303例非卵巢癌患者(对照组)的个人资料进行集中抽查和分析。卵巢癌的相对风险与口服避孕药的使用有关，根据研究、年龄、产次和子宫切除进行分层。结果发现，总共有7308例(31%)的病例和32717例对照组(37%)使用过口服避孕药，平均使用时间为4。4和5。分别为0年。癌症诊断的中位数年是1993年，当时患者的平均年龄为56岁。女性使用口服避孕药的时间越长，患卵巢癌的风险降低越大(p
Background Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects.Methods Individual data for 23 257 women with ovarian cancer (cases) and 87 303 without ovarian cancer (controls) from 45 epidemiological studies in 21 countries were checked and analysed centrally. The relative risk of ovarian cancer in relation to oral contraceptive use was estimated, stratifying by study, age, parity, and hysterectomy.Findings Overall 7308 (31%) cases and 32 717 (37%) controls had ever used oral contraceptives, for average durations among users of 4 . 4 and 5 . 0 years, respectively. The median year of cancer diagnosis was 1993, when cases were aged an average of 56 years. The longer that women had used oral contraceptives, the greater the reduction in ovarian cancer risk (p