Prevalence and implication of a newly identified infectious agent (SEN virus) in Taiwan
Prevalence and implication of a newly identified infectious agent (SEN virus) in Taiwan
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DOI：
10.1086/338472
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发表时间：
2002-02-01
影响因子：
6.4
通讯作者：
Chen, DS
中科院分区：
文献类型：
--
作者：
Kao, JH;Chen, W;Chen, DS
为了调查台湾最近发现的SEN病毒（SENV）的流行率和临床相关性，在高危人群、肝病患者和健康成人中研究了2种SENV变体（SENV-D和SENV-H）。SENV-D和/或SENV-H（SENV-D/H）感染在高危人群（54%-90%）和慢性B肝炎（41%）、乙型肝炎相关肝细胞癌（HCC）（54%）、慢性丙型肝炎（67%）和丙型肝炎相关HCC（76%）患者中比健康成人（15%）更常见。SENV-D/H感染的患病率在非甲型至戊型暴发性肝炎患者（30%）和健康成人之间相当。大多数单独感染SENV-D/H的受试者没有或轻度肝炎，SENV-D/H与慢性肝炎B或C的合并感染与肝脏疾病的证据增加和HCC的风险无关。这些结果表明，SENV-D/H感染在台湾的高危人群中很常见，但SENV-D/H感染与肝炎无关。
To investigate the prevalence and clinical relevance of a recently identified SEN virus (SENV) in Taiwan, 2 SENV variants (SENV-D and SENV-H) were studied in high-risk persons, patients with liver disease, and healthy adults. SENV-D and/or SENV-H (SENV-D/H) infections were more frequent in high-risk groups (54%-90%) and in patients with chronic hepatitis B (41%), hepatitis B-related hepatocellular carcinoma (HCC) (54%), chronic hepatitis C (67%), and hepatitis C-related HCC (76%) than in healthy adults (15%). The prevalence of SENV-D/H infection was comparable between patients with non-A to E fulminant hepatitis (30%) and healthy adults. Most subjects with SENV-D/H infection alone had no or mild hepatitis, and coinfection of SENV-D/H with chronic hepatitis B or C was not associated with increased evidence of liver disease and the risk of HCC. These results suggest that SENV-D/H infection is common in high-risk groups in Taiwan but that SENV-D/H infection is not associated with hepatitis.