The CFTA method: a reliable procedure for the determination of the absolute configuration of chiral primary amines by 1H NMR spectroscopic analysis.
The CFTA method: a reliable procedure for the determination of the absolute configuration of chiral primary amines by 1H NMR spectroscopic analysis.
复制标题
CFTA 方法：通过 1 H NMR 光谱分析测定手性伯胺绝对构型的可靠方法。
DOI：
10.1002/anie.200600157
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Unkefer,CliffordJ
中科院分区：
文献类型：
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作者：
Takeuchi,Yoshio;Segawa,Masaru;Fujisawa,Hidehito;Omata,Kenji;Lodwig,SiegfriedN;Unkefer,CliffordJ
令人惊讶的是，CFTA酰胺的稳定的反周面构象形成了一种新的和非常可靠的方法的基础，用于通过1H NMR光谱确定手性伯胺的绝对构型（见图）。CFTA= α-氰基-α-氟-对甲苯乙酸。（化学方程式）。
Surprisingly stable anti-periplanar conformers of CFTA amides form the basis of a new and very reliable method for determining the absolute configuration of chiral primary amines by 1 H NMR spectroscopy (see picture). CFTA= α-cyano-α-fluoro-p-tolylacetic acid.(Chemical Equation Presented).