Cytokine levels in euthymic bipolar patients
Cytokine levels in euthymic bipolar patients
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DOI：
10.1016/j.jad.2010.04.027
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发表时间：
2010-11-01
影响因子：
6.6
通讯作者：
Nutt, David J.
中科院分区：
文献类型：
--
作者：
Guloksuz, Sinan;Cetin, Esin Aktas;Nutt, David J.
背景：双相情感障碍的病理生理尚不完全清楚。基于细胞因子在神经免疫调节中的作用，一些研究调查了细胞因子在精神疾病中的可能作用；然而，双相情感障碍的研究结果仍然有限和矛盾，大多数研究都集中在躁狂或抑郁发作上。这些研究表明躁狂和抑郁发作都可能是促炎状态。本研究旨在确定在心境双相患者和健康对照者之间是否存在与药物作用无关的细胞因子水平的持久差异。方法：研究纳入31例常郁双相患者，其中16例为无药物治疗（MF）， 15例为锂单药治疗（LM）； 16例为健康志愿者，测定血清细胞因子水平。这三个组在年龄、性别和种族方面是相同的。流式细胞术检测各组ifn - γ、tnf - α、IL-2、IL-4、IL-5、IL-10水平。结果：MF心境双相患者与健康对照间细胞因子水平无显著差异。LM型心境双相患者的tnf - α和IL-4水平高于MF型心境双相患者和对照组。局限性：小而严格选择的研究样本可能会限制研究结果的普遍性。结论：MF心境双相患者的细胞因子产生与健康对照相似。本研究表明，促炎状态在心境愉悦时消退，锂对细胞因子谱有影响，这可能在研究双相情感障碍疾病相关免疫病理时产生混淆因素。(C) 2010 Elsevier B.V.版权所有
Background: The pathophysiology of bipolar disorder is not thoroughly understood. Several studies have investigated the possible role of cytokines in psychiatric disorders, based on their role in neuro-immune modulation; however, findings in studies on bipolar disorder remain limited and contradictory, and most studies have focused on either manic or depressive episodes. These studies suggest that both manic and depressive episodes could be pro-inflammatory states. The present study aimed to determine whether there are enduring differences in cytokine levels-unrelated to the effects of medication-between euthymic bipolar patients and healthy controls.Methods: The study included 31 euthymic bipolar patients-16 medication-free (MF) and 15 on lithium monotherapy (LM) and 16 healthy volunteers in whom serum cytokine levels were measured. The 3 groups were homogenous in terms of age, gender, and ethnicity. IFN-gamma, TNF-alpha, IL-2, IL-4, IL-5, and IL-10 levels were measured in all groups using flow cytometry.Results: There were no differences in cytokine levels between MF euthymic bipolar patients and healthy controls. TNF-alpha and IL-4 levels in LM euthymic bipolar patients were higher than in both the MF euthymic bipolar patients and controls.Limitations: The small and strictly selected study sample could limit the generalizability of the findings.Conclusions: Cytokine production in MF euthymic bipolar patients was similar to that in healthy controls.The present study shows that the pro-inflammatory state resolves in euthymia and that lithium had an influence on the cytokine profile, which could create a confounding factor while investigating disease- related immunopathology of bipolar disorder. (C) 2010 Elsevier B.V. All rights reserved.