Pivampicillin and ampicillin in bile, portal and peripheral blood
Pivampicillin and ampicillin in bile, portal and peripheral blood
复制标题
胆汁、门脉和外周血中的哌氨西林和氨苄西林
DOI：
10.1002/cpt1976195part1587
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发表时间：
1976
影响因子：
6.7
通讯作者：
J. Hansen
中科院分区：
文献类型：
--
作者：
B. Lund;J. Kampmann;F. Lindahl;J. Hansen
7例门静脉插管、胆总管T管的患者口服700 mg匹氨西林后，同时测定门静脉血、外周血和胆汁中未水解匹氨西林和氨苄西林的浓度。在门静脉和外周循环中，未水解的匹氨西林浓度始终低于氨苄西林水平的1%，表明肠粘膜对匹氨西林水解的有效性。通过直接测量建立了肝脏以浓度梯度将氨苄青霉素排泄到胆汁中的能力的证据。只有大约 1% 的剂量可以在胆汁中回收。导管本身引起的药物吸收莫名其妙地减少了约 70%。
In 7 patients with a catheter in the portal vein and a T tube in the common bile duct, the concentration of unhydrolyzed pivampicillin and of ampicillin was measured simultaneously in portal and peripheral blood and in bile after oral administration of 700 mg pivampicillin. In both portal and peripheral circulation the concentration of unhydrolyzed pivampicillin was always less than 1% of the levels of ampicillin, indicating the effectiveness of the intestinal mucosa in the hydrolysis of pivampicillin. Evidence for the ability of the liver to excrete ampicillin against a concentration gradient into the bile was established by direct measurements. Only about 1% of the dose given could be recovered in the bile. There was an unexplained reduction of about 70% in the absorption of the drug induced by the catheter itself.