The development of a New Zealand twin register.
The development of a New Zealand twin register.
复制标题
新西兰双胞胎登记册的开发。
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
A. Veale
中科院分区：
文献类型：
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作者：
J. Findlay;T. Kjellstrom;A. Veale
总结
几个国家使用了大规模的双登记册进行慢性病的流行病学研究。它们使分析环境因素对健康的影响成为可能，而遗传因素是受控制的。
建立了一个双胞胎登记册，登记了1926年至1935年在新西兰出生的所有非毛利人的已婚双胞胎。多胞胎总数为2 765例（双胞胎2 750例），多胞胎出生率为活产婴儿的1.1%。每对双胞胎中约有三分之一是男女混合的。经过多阶段的记录搜索过程，1998对双胞胎被追踪到一个地址或死亡记录，另有580对双胞胎被追踪到一个双胞胎。这对双胞胎的新生儿死亡率约为8%，远高于1930年报告的2.4%。
这对双胞胎目前的住址在选民名册中进行了搜索，共有1428对双胞胎都还活着。计划用国际商定的调查表收集基线环境接触数据，并在今后跟踪双胞胎的死亡率。
Summary
Large-scale twin registers have been used in several countries for epidemiological studies of chronic diseases. They make possible an analysis of the health effects of environmental factors while genetic factors are controlled.
A twin register comprising all live nuptial non-Maori twins born in 1926 to 1935 in New Zealand was developed. The total number of multiple births was 2765 (with 2750 twin births) giving a multiple birth ratio of 1.1 per cent of live births. About one third each of the twin pairs were mixed-sex, male and female pairs. After a multi-stage record search process 1998 pairs had been traced to an address or a death record and an additional 580 pairs had one twin traced. The neonatal mortality rate for the twins was about 8 per cent, much higher than the 2.4 per cent reported for all births in 1930.
The current addresses of the twins were searched in electoral rolls and a total of 1428 pairs where both are alive have been located. It is planned to collect base-line environmental exposure data with an internationally agreed questionnaire and to follow-up the mortality of the twins in the future.