Posterior fossa magnetic resonance imaging in autism
Posterior fossa magnetic resonance imaging in autism
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DOI：
10.1097/00004583-200106000-00011
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发表时间：
2001-06-01
影响因子：
13.3
通讯作者：
Keshavan, MS
中科院分区：
文献类型：
--
作者：
Hardan, AY;Minshew, NJ;Keshavan, MS
目的：目的：探讨非智力迟钝的自闭症青少年和成人的颅后窝结构的大小和体积是否异常。方法：对16名自闭症患者和19名健康对照组进行冠状面磁共振成像扫描，测量小脑、小脑蚓部和脑干的体积。为了与以前的研究进行比较，面积测量中脑，笔，髓质，总小脑蚓部，其三个亚区也获得了较大的样本22自闭症男性（平均年龄：22.4岁;范围：12.2-51.8岁）和22个单独匹配的控制（平均年龄22.4岁;范围：12.9-52.2岁）。结果如下：小脑和小脑半球的总体积显着更大的自闭症受试者与不校正总脑体积。两组间的小脑蚓部、脑干和所有面积测量值均无显著差异。结论：自闭症患者的小脑体积增加，这与这种发育障碍中报告的区域和总大脑大小的增加一致。这一发现也与来自神经病理学和神经心理学研究的小脑异常的证据相一致，这些研究指出该结构作为复杂神经系统的一部分在自闭症的病理生理学中的作用。
Objective: To determine whether the sizes and volumes of the posterior fossa structures are abnormal in non-mentally retarded autistic adolescents and adults. Method: Volume measurements of the cerebellum, vermis, and brainstem were obtained from coronal magnetic resonance imaging scans in 16 autistic subjects and 19 group-matched healthy controls. For the purpose of comparison with previous studies, area measurements of the midbrain, pens, medulla, total cerebellar vermis, and its three subregions were also obtained from a larger sample of 22 autistic males (mean age: 22.4 years; range: 12.2-51.8 years) and 22 individually matched controls (mean age 22.4 years; range: 12.9-52.2 years). Results: The total volume of the cerebellum and the cerebellar hemispheres were significantly larger in the autistic subjects with and without correcting for total brain volume. Volumes of the vermis and the brainstem and all area measurements did not differ significantly between groups. Conclusions: There is an increase in the volume of the cerebellum in people with autism consistent with the increase in regional and total brain size reported in this developmental disorder. This finding is also concordant with evidence of cerebellar abnormalities from neuropathological and neuropsychological studies that point to the role of this structure, as part of a complex neural system, in the pathophysiology of autism.