Histone Lysine Demethylases and Their Functions in Plants
Histone Lysine Demethylases and Their Functions in Plants
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组蛋白赖氨酸去甲基酶及其在植物中的功能
DOI：
10.1007/s11105-013-0673-1
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发表时间：
2014-04-01
影响因子：
2.1
通讯作者：
Wu, Keqiang
中科院分区：
文献类型：
--
作者：
Luo, Ming;Hung, Fu-Yu;Wu, Keqiang
组蛋白甲基化是将甲基转移到组蛋白尾部的赖氨酸或赖氨酸残基上，在真核细胞基因表达调控中起着重要作用。组蛋白甲基化水平受组蛋白甲基转移酶和组蛋白去甲基化酶调节。真核生物中存在两种类型的组蛋白赖氨酸脱甲基酶（KDM）：KDM 1/LSD 1样脱甲基酶和含JmjC结构域的脱甲基酶。KDM可以通过组蛋白修饰直接调节基因表达，也可以通过DNA甲基化和siRNA再生间接调节基因表达。近年来的研究表明，KDMs在植物生长发育过程中起着重要的调控作用，如开花时间控制、激素反应和昼夜节律调节等。
Histone methylation-transfer of methyl groups to lysines or arginines residues of histone tails-plays an important role in the regulation of gene expression in eukaryotic cells. Histone methylation levels are regulated by histone methyltransferases and histone demethylases. There are two types of histone lysine demethylases (KDMs) in eukaryotes: KDM1/LSD1-like and JmjC domain-containing demethylases. KDMs can regulate gene expression directly through histone modification or indirectly through DNA methylation and siRNA regeneration. Recent studies indicate that KDMs play important regulatory roles in plant growth and developmental processes such as flowering time control, hormone response and circadian regulation.