IRON-DEFICIENCY AND THE IMMUNE-RESPONSE
IRON-DEFICIENCY AND THE IMMUNE-RESPONSE
复制标题
DOI：
10.1093/ajcn/46.2.329
复制
发表时间：
1987-08-01
影响因子：
7.1
通讯作者：
DALLMAN, PR
中科院分区：
文献类型：
--
作者：
DALLMAN, PR
缺铁作为一个公共卫生问题的重要性最终取决于其对健康造成的后果的严重性。研究最广泛的缺铁后果涉及工作表现和免疫功能。对工作绩效影响的重要性已被普遍接受。相反，关于缺铁对免疫功能影响的数据常常被认为是混乱和矛盾的。通过对相关文献的重新检查，似乎可以得出这样的结论：在缺铁患者的实验条件下，细胞介导的免疫和中性粒细胞杀死几种细菌的能力的异常已经得到了很好的证实。目前尚不确定这些异常是否会导致感染的发生率和持续时间增加。这个领域还需要仔细研究。
The importance of iron deficiency as a public health problem is based ultimately on the seriousness of its consequences on health. The most extensively investigated consequences of iron deficiency involve work performance and immune function. The significance of the effects on work performance are generally accepted. In contrast, data on the influence of iron deficiency on immune function are often perceived as being confusing and contradictory. From reexamination of relevant literature, it seems safe to conclude that abnormalities in cell-mediated immunity and ability of neutrophils to kill several types of bacteria are well established under experimental conditions in iron-deficient patients. It remains uncertain whether these abnormalities result in an increased incidence and duration of infections. This area still requires careful study.