Uric acid in metabolic syndrome: From an innocent bystander to a central player.
Uric acid in metabolic syndrome: From an innocent bystander to a central player.
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DOI：
10.1016/j.ejim.2015.11.026
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发表时间：
2016-04
影响因子：
8
通讯作者：
Johnson RJ
中科院分区：
文献类型：
--
作者：
Kanbay M;Jensen T;Solak Y;Le M;Roncal-Jimenez C;Rivard C;Lanaspa MA;Nakagawa T;Johnson RJ
尿酸曾被视为嘌呤代谢的惰性代谢终产物，最近已与许多慢性疾病有关，包括高血压、代谢综合征、糖尿病、非酒精性脂肪肝和慢性肾病。多项实验和临床研究支持尿酸是这些病症的致病因素。在这里，我们讨论尿酸与代谢和心血管疾病相关的一些主要机制。目前，了解尿酸在这些疾病中的重要性的关键将是进行大型临床试验，评估降低尿酸对硬临床结果的影响。尿酸升高可能是代谢和心血管疾病更重要的可治愈危险因素之一。
Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease. Several experimental and clinical studies support a role for uric acid as a contributory causal factor in these conditions. Here we discuss some of the major mechanisms linking uric acid to metabolic and cardiovascular diseases. At this time the key to understanding the importance of uric acid in these diseases will be the conduct of large clinical trials in which the effect of lowering uric acid on hard clinical outcomes is assessed. Elevated uric acid may turn out to be one of the more important remediable risk factors for metabolic and cardiovascular diseases.