Smoking, genes encoding dopamine pathway and risk for Parkinson's disease
Smoking, genes encoding dopamine pathway and risk for Parkinson's disease
复制标题
DOI：
10.1016/j.neulet.2010.06.085
复制
发表时间：
2010-09-20
影响因子：
2.5
通讯作者：
Chan, Piu
中科院分区：
文献类型：
--
作者：
Gu, Zhuqin;Feng, Xiuli;Chan, Piu
在许多研究中，吸烟与帕金森病（PD）呈负相关，但最近在中国的一项研究发现，吸烟增加了PD的风险。与多巴胺代谢相关的基因变异被发现增加PD的风险，也与吸烟行为有关。研究中国人群中吸烟与帕金森病的关系，并确定多巴胺代谢相关基因的遗传变异是否影响吸烟与帕金森病风险之间的关系。从宣武医院招募中国PD患者。从社区中抽取对照样本。通过面对面访谈收集有关终生吸烟行为的详细信息。采用PCR-RFLP、DHPLC和测序方法检测SLC 6A 3基因VNTR、COMT Val 108/158 Met和MAO-B内含子13 A/G多态性。采用卡方检验和Logistic回归模型进行分析。本研究入组了176例PD病例和354例对照。23.9%的病例是吸烟者，而对照组为48.0%。曾经吸烟与PD呈负相关（比值比= 0.14，95%CI 0.08-0.26，经年龄和性别校正）。上述基因多态性均与PD风险或吸烟无关。当每个变量都包括在logistic回归模型中时，吸烟与PD之间的负相关性保持不变，并且吸烟与变量之间的相互作用在模型中不显著。我们的数据支持在中国人群中与吸烟相关的PD风险降低。这些与DA摄取和代谢相关的基因变体不影响吸烟和PD之间的负相关性。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Smoking has been reported to be inversely associated with Parkinson's disease (PD) in many studies, but a recent study in China found that smoking increased the risk of PD. Variants in genes associated with dopamine metabolism found to increase the risk for PD have also been associated with smoking behavior. To investigate the association between smoking and PD in a Chinese population and determine whether the genetic variants of genes involved in dopamine metabolism influence the relationship between smoking and risk for PD. Chinese PD patients were recruited from Xuanwu Hospital. Controls were sampled from community. Detailed information on life-long smoking behavior was collected by face-to-face interview. Genotypes were determined for SLC6A3 VNTR, COMT Val108/158Met and MAO-B intron13 A/G polymorphisms by PCR-RFLP, DHPLC and sequencing. Chi-square and logistic regression model were used in the analysis. 176 PD cases and 354 controls were enrolled in this study. 23.9% cases are smokers, compared to 48.0% in controls. Ever smoking is inversely associated with PD (odds ratio = 0.14, 95% CI 0.08-0.26, adjusted for age and gender). None of the above-mentioned genetic polymorphisms was associated with PD risk or smoking. When each variant was included in the logistic regression model, the inverse association between smoking and PD remained the same, and the interactions between smoking and variants were not significant in the model. Our data support a reduction of PD risk associated with smoking in a Chinese population. These variants of genes associated with DA uptake and metabolism do not affect the inverse association between smoking and PD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.