Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium
Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium
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DOI：
10.3945/ajcn.110.006866
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发表时间：
2011-02-01
影响因子：
7.1
通讯作者：
Lopez-Miranda, Jose
中科院分区：
文献类型：
--
作者：
Marin, Carmen;Ramirez, Rafael;Lopez-Miranda, Jose
背景：内皮功能障碍是动脉粥样硬化疾病过程中的一个基本步骤。内皮的活化或损伤导致多种炎性病症，包括微粒的释放。目的：研究膳食脂肪对老年人内皮细胞微粒（Endothelial microparticles，EMPs）和内皮祖细胞（endothelial progenitor cells，EPCs）释放的影响（10名男性和10名女性）消耗3种饮食后，随机交叉设计，每4周：饱和脂肪酸饮食，低脂肪，高碳水化合物饮食和地中海饮食（MedDiet）富含单不饱和脂肪酸。我们研究了总微粒、活化内皮细胞的EMP（活化EMP）、凋亡内皮细胞的EMP（凋亡EMP）、EPC、氧化应激变量和缺血反应性充血（IRH）。结果：MedDiet导致总微粒、活化EMP和凋亡EMP浓度较低，EPC数量较其他饮食高（P < 0.001）。我们检测到较低的超氧化物歧化酶活性（P < 0.001），较高的血浆β-胡萝卜素浓度（P < 0.001），和较低的尿异前列腺素和血浆硝基酪氨酸浓度后消费的MedDiet比消费后的其他2饮食（P < 0.05）。结论：与其他2种饮食相比，MedDiet饮食可减少内皮损伤和功能障碍，并改善内皮再生能力。美国临床营养杂志2011;93：267-74。
Background: Endothelial dysfunction is a fundamental step in the atherosclerotic disease process. Activation or injury of the endothelium leads to a variety of inflammatory disorders, including the release of microparticles. Endothelial progenitor cells may contribute to the maintenance of the endothelium by replacing injured mature endothelial cells.Objective: We studied the influence of dietary fat on the release of endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs) in elderly subjects.Design: Twenty healthy, elderly subjects (10 men and 10 women) consumed 3 diets following a randomized crossover design, each for 4 wk: a saturated fatty acid diet; a low-fat, high-carbohydrate diet; and a Mediterranean diet (MedDiet) enriched in monounsaturated fatty acids. We investigated total microparticles, EMPs from activated endothelial cells (activated EMPs), EMPs from apoptotic endothelial cells (apoptotic EMPs), EPCs, oxidative stress variables, and ischemic reactive hyperemia (IRH).Results: The MedDiet led to lower total microparticle, activated EMP, and apoptotic EMP concentrations and higher EPC numbers than did the other diets (P < 0.001). We detected lower superoxide dismutase activity (P < 0.001), a higher plasma beta-carotene concentration (P < 0.001), and lower urinary isoprostane and plasma nitrotyrosine concentrations after consumption of the MedDiet than after consumption of the other 2 diets (P < 0.05). Furthermore, the occurrence of IRH was higher after consumption of the MedDiet than after consumption of the other 2 diets (P < 0.05).Conclusion: Consumption of the MedDiet induces a reduction in endothelial damage and dysfunction, which is associated with an improvement in the regenerative capacity of the endothelium, in comparison with 2 other diets. Am J Clin Nutr 2011;93:267-74.